All things CoronaVirus

The odds are excellent that you will leave this forum hating someone.

How many of your friends and family members have died of the Chinese Corona Virus?

0 people
44
64%
1 person.
10
14%
2 people.
3
4%
3 people.
5
7%
More.
7
10%
 
Total votes: 69

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MDlaxfan76
Posts: 26411
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Re: All things CoronaVirus

Post by MDlaxfan76 »

wgdsr wrote: Wed Jan 27, 2021 12:10 pm if i may, we'd all do well to have a larger amount of tolerance for opposing views. and not read into what others are saying as much with our own proclamations of what they mean. all sides. at least more of the time. the staccato and not full explanation of internet posting breeds it, and interpretation can run in multiple directions.

we all (or most) get snippy at times and i don't know if that's to be expected, but there's certainly room to be aware of it all.

also probably a good idea not to say someone's part of the problem if it's already an elevated debate. or "who the **** said that?" frustration abounds these days. guilty as charged meeself.
Good advice, at least among the rational non-bomb throwers on here. There's been lots of good spirited debate among those with different perspectives, and maybe even more importantly, lots of information sharing.

And certainly a fair observation that all (I can't think of anyone this doesn't apply to, most definitely including myself) get 'snippy' at times.

Unfortunately there are some on these threads, past and present, who blast off at every turn, literally, full of themselves as righteous in their anger but really propelled by political disinformation, wildly personally insulting in the process. It really is indeed 'part of the problem' we have with virus mitigation that so many in our society have decided to buy into the most egregious disinformation....and act upon it in ways that, in aggregate, promote virus spread.

I was just talking with an 89 year old woman whose son had taken her for a first vaccine shot this morning (hooray!). They'd gone to a drive thru at Starbucks and were shocked by a loud, near violent argument they watched while in line as a maskless woman tried to enter the shop but was being rebuffed...blew her top at the staff...
Last edited by MDlaxfan76 on Wed Jan 27, 2021 6:43 pm, edited 1 time in total.
wgdsr
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Re: All things CoronaVirus

Post by wgdsr »

njbill wrote: Wed Jan 27, 2021 3:10 pm Given that timeframe (not good in my view), I wonder how many they would have available right off the bat, if they get approved?
here is what i posted a couple weeks ago, so some time elapse:
wgdsr wrote: Wed Jan 20, 2021 9:06 am https://www.forbes.com/sites/greatspecu ... on-delays/
https://www.msn.com/en-us/news/us/johns ... li=BBnb7Kz

good news, bad news. prelim results on safety and developing anti-bodies for jnj vaxx looks v good (see link 1 to nejm study) we'll see on illness prevention maybe soon enough.

without giving a full explanation, jnj had plans to start out very slow with production, and now that's delayed. maybe substantially. tho they do mention they may be caught up by april, which looks like it was in their plans to be the big 1st month anyway. tbd.

the fda took approx one month for pfizer and moderna approval, and i suspect something there or shorter here. read they've been updating all along to fda on safety where moderna and pfizer was not so much, for whatever reason. so maybe approval late feb, with no vaccine to give out.
here is the nyt article if the msn copy is no longer any good:
https://www.nytimes.com/2021/01/13/heal ... ogin=email

here are some other prelim details on safety and antibodies:
https://www.cnbc.com/2021/01/13/covid-v ... ponse.html

here is a board member popping off a week ago that they can do still do 100 million by april "or so":
https://www.cnbc.com/2021/01/21/jj-plan ... -says.html

so contract (from nyt) looks like it was something close to:
12 million by end feb
more in march
60 million by end april
100 million by june

and trailing on production. for now. will they catch up? anyone's guess.
ggait
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Re: All things CoronaVirus

Post by ggait »

a fan wrote: Wed Jan 27, 2021 1:33 pm
JoeMauer89 wrote: Wed Jan 27, 2021 11:47 am What's your obsession with how many deaths are acceptable to me?
As for this----the reason is obvious, and you know it.

I'm simply pointing out that you are going to tell us that everything is fine, no matter how many people die from Covid.
Not an obsession -- but a rational/logical way of making decisions which involve trade offs.

Personally, my number was 200k deaths way back when the consensus projections were 75k ballpark and we all were doing lock downs. Assuming that almost all the deaths would be clustered in frail elderly, I thought it was an acceptable choice to open things up more so long as we didn't blow past that milestone.

At the time, many on here thought I was hard hearted. Now I look naive-ly optimistic. Since we're going to hit 600k even after taking a huge hit on jobs, economy, school education, etc.

Other peer countries (UK, Spain, Italy, France, Sweden) have done pretty bad too. Although I suspect our performance is the worst over the past 9 months. Since those countries got hit so hard in the first 2-3 months when so much less was known.
Boycott stupid. If you ignore the gator troll, eventually he'll just go back under his bridge.
njbill
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Re: All things CoronaVirus

Post by njbill »

wgdsr wrote: Wed Jan 27, 2021 4:53 pm
njbill wrote: Wed Jan 27, 2021 3:10 pm Given that timeframe (not good in my view), I wonder how many they would have available right off the bat, if they get approved?
here is what i posted a couple weeks ago, so some time elapse:
wgdsr wrote: Wed Jan 20, 2021 9:06 am https://www.forbes.com/sites/greatspecu ... on-delays/
https://www.msn.com/en-us/news/us/johns ... li=BBnb7Kz

good news, bad news. prelim results on safety and developing anti-bodies for jnj vaxx looks v good (see link 1 to nejm study) we'll see on illness prevention maybe soon enough.

without giving a full explanation, jnj had plans to start out very slow with production, and now that's delayed. maybe substantially. tho they do mention they may be caught up by april, which looks like it was in their plans to be the big 1st month anyway. tbd.

the fda took approx one month for pfizer and moderna approval, and i suspect something there or shorter here. read they've been updating all along to fda on safety where moderna and pfizer was not so much, for whatever reason. so maybe approval late feb, with no vaccine to give out.
here is the nyt article if the msn copy is no longer any good:
https://www.nytimes.com/2021/01/13/heal ... ogin=email

here are some other prelim details on safety and antibodies:
https://www.cnbc.com/2021/01/13/covid-v ... ponse.html

here is a board member popping off a week ago that they can do still do 100 million by april "or so":
https://www.cnbc.com/2021/01/21/jj-plan ... -says.html

so contract (from nyt) looks like it was something close to:
12 million by end feb
more in march
60 million by end april
100 million by june

and trailing on production. for now. will they catch up? anyone's guess.
Thanks. Very helpful.

Anything is better than nothing. Sooner is better than later. Sounds like this won’t be a game changer in the short run, but that it may at least make a dent.
wgdsr
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Re: All things CoronaVirus

Post by wgdsr »

njbill wrote: Wed Jan 27, 2021 5:12 pm
wgdsr wrote: Wed Jan 27, 2021 4:53 pm
njbill wrote: Wed Jan 27, 2021 3:10 pm Given that timeframe (not good in my view), I wonder how many they would have available right off the bat, if they get approved?
here is what i posted a couple weeks ago, so some time elapse:
wgdsr wrote: Wed Jan 20, 2021 9:06 am https://www.forbes.com/sites/greatspecu ... on-delays/
https://www.msn.com/en-us/news/us/johns ... li=BBnb7Kz

good news, bad news. prelim results on safety and developing anti-bodies for jnj vaxx looks v good (see link 1 to nejm study) we'll see on illness prevention maybe soon enough.

without giving a full explanation, jnj had plans to start out very slow with production, and now that's delayed. maybe substantially. tho they do mention they may be caught up by april, which looks like it was in their plans to be the big 1st month anyway. tbd.

the fda took approx one month for pfizer and moderna approval, and i suspect something there or shorter here. read they've been updating all along to fda on safety where moderna and pfizer was not so much, for whatever reason. so maybe approval late feb, with no vaccine to give out.
here is the nyt article if the msn copy is no longer any good:
https://www.nytimes.com/2021/01/13/heal ... ogin=email

here are some other prelim details on safety and antibodies:
https://www.cnbc.com/2021/01/13/covid-v ... ponse.html

here is a board member popping off a week ago that they can do still do 100 million by april "or so":
https://www.cnbc.com/2021/01/21/jj-plan ... -says.html

so contract (from nyt) looks like it was something close to:
12 million by end feb
more in march
60 million by end april
100 million by june

and trailing on production. for now. will they catch up? anyone's guess.
Thanks. Very helpful.

Anything is better than nothing. Sooner is better than later. Sounds like this won’t be a game changer in the short run, but that it may at least make a dent.
yeah. i would've expected jnj to be ready. oh, well. we do i guess have an option for another 200 million, not executed yet. ha!
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RedFromMI
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Re: All things CoronaVirus

Post by RedFromMI »

Plitidepsin Could Treat COVID-19, Preclinical Data Suggest
https://www.medscape.com/viewarticle/94 ... c_tw_share
Although the evidence is preclinical, a new study shows that the antiviral agent plitidepsin (Aplidin) can block proliferation of the SARS-CoV-2 virus in different cell lines and in the lungs of mice.

The antiviral activity of plitidepsin was nearly 28-fold stronger than that of remdesivir against SARS-CoV-2 in the in vitro research. The researchers also note that the two agents act on different targets, so remdesivir and plitidepsin, if cleared for use, could provide an additive effect when given in combination.

"The potency of the inhibitor is quite amazing," senior author Adolfo Garcia-Sastre, PhD, told Medscape Medical News.

Given prophylactically, plitidepsin also reduced viral replication in the lungs of two different mice models by two orders of magnitude.

Plitidepsin works by inhibiting the eEF1A protein in the host, not the virus, which could be an advantage because it avoids problems associated with future viral resistance.

The study was published online January 25 in Science.
Early Data, Early Administration

The preclinical efficacy shown in this study and in a phase 1/2 clinical trial from the manufacturer suggest "that plitidepsin should be strongly considered for expanded clinical trials for the treatment of COVID-19," the researchers note.

Still, it's early days. "We have found a potent inhibitor of SARS-CoV-2 replication, but clinical trials are still needed to find whether it provides a benefit to patients," added Garcia-Sastre, director of the Global Health Emerging Pathogens Institute at Icahn School of Medicine at Mount Sinai in New York City.

Because plitidepsin is an antiviral agent, "it inhibits the replication of the virus and needs to be given during the active replication phase of COVID-19. Similar to remdesivir and all other antiviral drugs, the sooner it is given to you, the better chance it has of being effective," lead author Kris M. White, PhD, assistant professor of microbiology, Icahn School of Medicine at Mount Sinai, told Medscape Medical News.
A Paucity of Therapeutics

The investigators point out that current therapies for patients with COVID-19 include oxygen treatment, ventilation, remdesivir, and the steroid dexamethasone. They add that "remdesivir in particular has shown limited efficacy and dexamethasone is a steroid that does not directly inhibit viral replication.

"This leaves a continued need for the development or repurposing of antiviral drugs for the treatment of COVID-19," they note.

Given the need for effective therapeutics, they investigated the repurposing of existing agents. This led them to investigate the antiviral potential of plitidepsin against SARS-CoV-2. Plitidepsin was initially discovered in the sea squirt Aplidium albicans.
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holmes435
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Re: All things CoronaVirus

Post by holmes435 »

Updated vaccine stats: https://www.bloomberg.com/graphics/covi ... tribution/

Good news is that we're averaging over 1M doses per day for the past 5 days
wgdsr
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Re: All things CoronaVirus

Post by wgdsr »

i'm gonna be pis*ed if someone finds an effective and ubiquitous therapeutic before me on here.
a fan
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Re: All things CoronaVirus

Post by a fan »

wgdsr wrote: Wed Jan 27, 2021 5:43 pm i'm gonna be pis*ed if someone finds an effective and ubiquitous therapeutic before me on here.
:lol:

(and bonus for using the word ubiquitous)
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RedFromMI
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Re: All things CoronaVirus

Post by RedFromMI »

wgdsr wrote: Wed Jan 27, 2021 5:43 pm i'm gonna be pis*ed if someone finds an effective and ubiquitous therapeutic before me on here.
Hey, it just showed up in my Twitter feed...
wgdsr
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Re: All things CoronaVirus

Post by wgdsr »

RedFromMI wrote: Wed Jan 27, 2021 5:47 pm
wgdsr wrote: Wed Jan 27, 2021 5:43 pm i'm gonna be pis*ed if someone finds an effective and ubiquitous therapeutic before me on here.
Hey, it just showed up in my Twitter feed...
well then, if you can't tell me w.t.f. the sea squirt aplidium albicans are, i'll have take this with a grain of "salt".
6x6
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Re: All things CoronaVirus

Post by 6x6 »

holmes435 wrote: Wed Jan 27, 2021 5:41 pm Updated vaccine stats: https://www.bloomberg.com/graphics/covi ... tribution/

Good news is that we're averaging over 1M doses per day for the past 5 days
The wife and I received the first shot of the Moderna vaccine today and are scheduled to receive the second dose in 4 weeks. No side effects at all for her and just a minor change for me. She says the new look is better 8-)


https://img1.looper.com/img/gallery/doc ... 251766.jpg
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MDlaxfan76
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Re: All things CoronaVirus

Post by MDlaxfan76 »

6x6 wrote: Wed Jan 27, 2021 8:39 pm
holmes435 wrote: Wed Jan 27, 2021 5:41 pm Updated vaccine stats: https://www.bloomberg.com/graphics/covi ... tribution/

Good news is that we're averaging over 1M doses per day for the past 5 days
The wife and I received the first shot of the Moderna vaccine today and are scheduled to receive the second dose in 4 weeks. No side effects at all for her and just a minor change for me. She says the new look is better 8-)


https://img1.looper.com/img/gallery/doc ... 251766.jpg
:lol: Congrats on first step.
kramerica.inc
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Re: All things Chinese CoronaVirus

Post by kramerica.inc »

Local news in MD reporting 20k shots issued daily in MD this week.

Hogan pledging to open as many vaccine centers as possible- drugstores, dr offices etc.

The Wife’s college is opening up as a vaccine center next week.
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RedFromMI
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Re: All things CoronaVirus

Post by RedFromMI »

wgdsr wrote: Wed Jan 27, 2021 5:54 pm
RedFromMI wrote: Wed Jan 27, 2021 5:47 pm
wgdsr wrote: Wed Jan 27, 2021 5:43 pm i'm gonna be pis*ed if someone finds an effective and ubiquitous therapeutic before me on here.
Hey, it just showed up in my Twitter feed...
well then, if you can't tell me w.t.f. the sea squirt aplidium albicans are, i'll have take this with a grain of "salt".
You mean this:

Image
The ascidian Aplidium albicans was found in the Balearic Islands. The anticancer drug APLIDIN was originally found in this marine macroorganism and is now synthetically synthesized.
Typical Lax Dad
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Re: All things CoronaVirus

Post by Typical Lax Dad »

RedFromMI wrote: Wed Jan 27, 2021 10:19 pm
wgdsr wrote: Wed Jan 27, 2021 5:54 pm
RedFromMI wrote: Wed Jan 27, 2021 5:47 pm
wgdsr wrote: Wed Jan 27, 2021 5:43 pm i'm gonna be pis*ed if someone finds an effective and ubiquitous therapeutic before me on here.
Hey, it just showed up in my Twitter feed...
well then, if you can't tell me w.t.f. the sea squirt aplidium albicans are, i'll have take this with a grain of "salt".
You mean this:

Image
The ascidian Aplidium albicans was found in the Balearic Islands. The anticancer drug APLIDIN was originally found in this marine macroorganism and is now synthetically synthesized.
https://pubmed.ncbi.nlm.nih.gov/31476502/
“You lucky I ain’t read wretched yet!”
wgdsr
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Re: All things CoronaVirus

Post by wgdsr »

bit of a curveball
https://www.cnbc.com/2021/01/28/covid-v ... ctive.html

novavax in early with a uk trial. lot of cases over there.

only 60 some cases vs the mid/high 100s for pfizer and moderna, but originally they were looking at doing about that many for results. be interesting if the fda takes this up (<30,000 trial participants) before the u.s. results come up. or they combine.

we have a bead on novavax early production.
wgdsr
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Re: All things CoronaVirus

Post by wgdsr »

wgdsr wrote: Thu Jan 28, 2021 4:14 pm bit of a curveball
https://www.cnbc.com/2021/01/28/covid-v ... ctive.html

novavax in early with a uk trial. lot of cases over there.

only 60 some cases vs the mid/high 100s for pfizer and moderna, but originally they were looking at doing about that many for results. be interesting if the fda takes this up (<30,000 trial participants) before the u.s. results come up. or they combine.

we have a bead on novavax early production.
wow, that's amazing. it's a hoax, though. we don't really need it.

plus we have a lot of vaccine rolling out. but it does look like we should've boosted production 8 months ago with novavax. fail.
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holmes435
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Re: All things CoronaVirus

Post by holmes435 »

wgdsr wrote: Thu Jan 28, 2021 7:14 pm
wgdsr wrote: Thu Jan 28, 2021 4:14 pm bit of a curveball
https://www.cnbc.com/2021/01/28/covid-v ... ctive.html

novavax in early with a uk trial. lot of cases over there.

only 60 some cases vs the mid/high 100s for pfizer and moderna, but originally they were looking at doing about that many for results. be interesting if the fda takes this up (<30,000 trial participants) before the u.s. results come up. or they combine.

we have a bead on novavax early production.
wow, that's amazing. it's a hoax, though. we don't really need it.

plus we have a lot of vaccine rolling out. but it does look like we should've boosted production 8 months ago with novavax. fail.

You ok there sparky? Forget to switch accounts?

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Typical Lax Dad
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Re: All things CoronaVirus

Post by Typical Lax Dad »

https://apple.news/AiELdO2AnS4S5Nfx6QewERA

This is what I figured months ago when I saw the % of nursing home deaths in NY was lower than everywhere else....I haven’t checked but my guess is NY looks more like other states after this adjustment....common sense.
“You lucky I ain’t read wretched yet!”
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