jhu72 wrote: ↑Mon Apr 27, 2020 3:36 pm
kramerica.inc wrote: ↑Mon Apr 27, 2020 3:34 pm
What's the fatality rate of COVID once you're on a respirator?
In the US, something like 80%.
Kram,
I don't want to assume what your point is, but sounds like you're good with the 25% kidney failure in comparison to 80% death rate once on respirator?
That would indeed be a reasonable tradeoff if the Remdesivir was at the moment when ventilator would otherwise be necessary, improving mortality.
But only a small % of CV-19 patients actually get to the ventilator stage. Some die suddenly from heart issues, which adds to the death count, but these may or may not have been symptomatic at all...apparently a bunch of those don't even come to the hospital. But most never get to a ventilator.
Most patients eventually recover, though we think there's considerable damage to at least some portion of those who recover, so death is not the only negative outcome.
Point is that if the 25% kidney failure (or "deterioration") outcome is of those who would not have otherwise moved onto a ventilator, then that's an awful #.
But we don't really have enough data, at least not yet, to say that Remdesivir is or is not a good therapy for at least some patients at a particular point in the course of the disease and at particular dosages and in combination with other therapies.
We hope it will be both efficacious and safe.
and/or that other therapies will be even better.
and soon!