The MCLA National Championship opens today and these are the best game in order:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Minnesota | #4 | vs | #7 | Florida | 05/09/2022 |
| 2 | Clemson | #2 | vs | #12 | Cal Poly | 05/09/2022 |
| 3 | Concordia-Irvine | #6 | vs | #9 | Georgia Tech | 05/09/2022 |
| 4 | South Carolina | #3 | vs | #15 | Arizona | 05/09/2022 |
| 5 | Liberty | #8 | vs | #10 | Grand Canyon | 05/09/2022 |
| 6 | Boise State | #38 | vs | #1 | Virginia Tech | 05/09/2022 |
| 7 | USC | #24 | vs | #19 | Boston College | 05/09/2022 |
| 8 | Brigham Young | #5 | vs | #40 | Texas Christian | 05/09/2022 |
| 9 | College of Idaho | #29 | vs | #31 | UNC-Charlotte | 05/09/2022 |
| 10 | Kennesaw State | #13 | vs | #56 | Cal State San Marcos | 05/09/2022 |
| 11 | Utah | #26 | vs | #49 | North Dakota State | 05/09/2022 |
| 12 | Grand Valley State | #46 | vs | #36 | UC San Diego | 05/09/2022 |
| 13 | Montana | #47 | vs | #37 | Florida Gulf Coast | 05/09/2022 |
| 14 | Rhode Island | #53 | vs | #44 | Utah State | 05/09/2022 |
| 15 | Florida Atlantic | #69 | vs | #34 | St. Thomas | 05/09/2022 |
| 16 | Missouri State | #73 | vs | #54 | Montana State | 05/09/2022 |
