In the play-in game, #4 Onondaga (who is the only team to beat #1 Harford) lost to #5 Nassau. These are Saturday’s upcoming semifinal games:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Howard (MD) | #2 | vs | #3 | CCBC Essex | 05/14/2022 |
| 2 | Nassau | #5 | vs | #1 | Harford | 05/14/2022 |
