Best Upsets are marked with an asterisks*. Some teams are under-rated due to having limited quality wins.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Liberty | #4 | 11 – 8 | #8 | Virginia Tech | 04/24/2021 |
| 2* | Virginia Tech | #8 | 15 – 7 | #7 | Clemson | 04/23/2021 |
| 3 | LSU | #11 | 9 – 8 | #18 | Texas Christian | 04/25/2021 |
| 4 | Chapman | #1 | 16 – 12 | #29 | Arizona | 04/23/2021 |
| 5 | Texas Christian | #18 | 6 – 4 | #23 | Texas A&M | 04/24/2021 |
| 6 | Utah Valley | #9 | 15 – 8 | #38 | Utah State | 04/24/2021 |
| 7 | Missouri State | #10 | 25 – 7 | #45 | Kansas | 04/24/2021 |
| 8 | Auburn | #30 | 13 – 4 | #32 | Georgia | 04/25/2021 |
| 9 | LSU | #11 | 10 – 2 | #52 | Texas Tech | 04/24/2021 |
| 10 | Montana | #12 | 12 – 7 | #55 | UNLV | 04/24/2021 |
| 11 | Montana | #12 | 14 – 13 | #55 | UNLV | 04/23/2021 |
| 12 | North Dakota State | #27 | 6 – 4 | #50 | St. John’s | 04/23/2021 |
