All teams are ranked according to their Best Wins and Worst Losses in 2021. In other words, if an objectively pretty good team only has 2 wins, they will have a lower rank than they objectively should have.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Le Moyne | #1 | vs | #17 | Bentley | 04/17/2021 |
| 2 | Limestone | #14 | vs | #18 | Belmont Abbey | 04/16/2021 |
| 3 | Rockhurst | #32 | vs | #4 | UIndy | 04/17/2021 |
| 4 | UIndy | #4 | vs | #32 | Rockhurst | 04/17/2021 |
| 5 | Wingate | #5 | vs | #34 | Tusculum | 04/17/2021 |
| 6 | Catawba | #29 | vs | #23 | Queens | 04/17/2021 |
| 7 | Franklin Pierce | #44 | vs | #9 | Adelphi | 04/17/2021 |
| 8 | Lewis | #49 | vs | #6 | Lindenwood | 04/17/2021 |
| 9 | Lake Erie | #47 | vs | #12 | Seton Hill | 04/17/2021 |
| 10 | Lenoir-Rhyne | #3 | vs | #60 | Mars Hill | 04/17/2021 |
| 11 | Davenport | #54 | vs | #13 | Maryville | 04/17/2021 |
| 12 | Mercyhurst | #7 | vs | #61 | Alderson-Broaddus | 04/17/2021 |
| 13 | North Greenville | #36 | vs | #37 | Barton | 04/17/2021 |
| 14 | Anderson (SC) | #42 | vs | #33 | Coker | 04/17/2021 |
| 15 | Lees-McRae | #65 | vs | #10 | Mount Olive | 04/17/2021 |
| 16 | Molloy | #46 | vs | #35 | Walsh | 04/17/2021 |
| 17 | Montevallo | #25 | vs | #59 | Alabama Huntsville | 04/17/2021 |
| 18 | Chestnut Hill | #19 | vs | #66 | Felician | 04/17/2021 |
| 19 | Wilmington | #48 | vs | #38 | Dominican (NY) | 04/17/2021 |
| 20 | Wilmington | #48 | vs | #38 | Dominican (NY) | 04/16/2021 |
| 21 | Newberry | #20 | vs | #69 | Lincoln Memorial | 04/17/2021 |
| 22 | Georgian Court | #22 | vs | #70 | Post | 04/17/2021 |
| 23 | Saint Rose | #45 | vs | #57 | Assumption | 04/17/2021 |
| 24 | Shorter | #67 | vs | #40 | Lander | 04/17/2021 |
| 25 | Chowan | #64 | vs | #52 | Emmanuel (Ga.) | 04/17/2021 |
