Numerous Best Games this weekend, 2 Upsets, and 2 Best Upsets (marked with an asterisks below).
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Westlake (CA) | #6 | 20 – 10 | #11 | Crespi (CA) | 04/10/2021 |
| 2 | Tesoro (CA) | #8 | 9 – 8 | #14 | Newport Harbor (CA) | 04/10/2021 |
| 3 | St. Margaret’s (CA) | #4 | 11 – 9 | #25 | Loyola (CA) | 04/09/2021 |
| 4* | Corona del Mar (CA) | #38 | 18 – 8 | #10 | San Clemente (CA) | 04/10/2021 |
| 5 | San Marcos (CA) | #3 | 14 – 6 | #53 | La Jolla (CA) | 04/10/2021 |
| 6 | Santiago (CA) | #16 | 15 – 5 | #40 | King (CA) | 04/10/2021 |
| 7 | Patrick Henry (CA) | #17 | 6 – 3 | #56 | St. Augustine (CA) | 04/09/2021 |
| 8 | Westview (CA) | #29 | 4 – 2 | #54 | Mt. Carmel (CA) | 04/09/2021 |
| 9 | Culver City (CA) | #20 | 12 – 6 | #63 | Peninsula (CA) | 04/09/2021 |
| 10 | Santana (CA) | #35 | 9 – 3 | #88 | Point Loma (CA) | 04/10/2021 |
| 11 | Urban (CA) | #43 | 7 – 2 | #82 | SHCP (CA) | 04/09/2021 |
| 12 | Vista del Lago (CA) | #51 | 15 – 10 | #87 | Bella Vista (CA) | 04/10/2021 |
| 13 | Temecula Valley (CA) | #32 | 16 – 2 | #106 | Marina (CA) | 04/10/2021 |
| 14 | San Diego (CA) | #45 | 14 – 6 | #105 | Mission Bay (CA) | 04/09/2021 |
| 15* | Orange Lutheran (CA) | #77 | 16 – 3 | #73 | El Modena (CA) | 04/09/2021 |
| 16 | Norco (CA) | #78 | 14 – 4 | #101 | Roosevelt (CA) | 04/10/2021 |
