Numerous Best Games this weekend, 0 Upsets, and 0 Best Upsets (marked with an asterisks below).
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Bishop Chatard (IN) | #6 | 10 – 3 | #11 | Castle (IN) | 04/10/2021 |
| 2 | Bishop Chatard (IN) | #6 | 15 – 10 | #13 | Evansville North (IN) | 04/10/2021 |
| 3 | Homestead (IN) | #12 | 16 – 8 | #14 | Brownsburg (IN) | 04/11/2021 |
| 4 | Crown Point (IN) | #7 | 17 – 3 | #25 | Roncalli (IN) | 04/10/2021 |
| 5 | Homestead (IN) | #12 | 15 – 8 | #26 | Munster (IN) | 04/11/2021 |
| 6 | Brownsburg (IN) | #14 | 9 – 8 | #26 | Munster (IN) | 04/11/2021 |
| 7 | Chesterton (IN) | #19 | 9 – 5 | #32 | Plainfield (IN) | 04/10/2021 |
| 8 | Chesterton (IN) | #19 | 13 – 2 | #35 | Lawrence North (IN) | 04/10/2021 |
| 9 | Avon (IN) | #20 | 10 – 1 | #36 | Lafayette Harrison (IN) | 04/09/2021 |
| 10 | Bosse (IN) | #27 | 9 – 3 | #30 | South Gibson (IN) | 04/09/2021 |
