Numerous Best Games this weekend, 0 Upsets, and 0 Best Upsets (marked with an asterisks below).
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Oro Valley Wolverines (AZ) | #4 | 7 – 6 | #7 | Mt Ridge Mt. Lions (AZ) | 04/10/2021 |
| 2 | Corona del Sol Aztecs (AZ) | #6 | 10 – 4 | #9 | Red Mountain Mtn Lions (AZ) | 04/09/2021 |
| 3 | Chaparral Firebirds (AZ) | #3 | 13 – 1 | #13 | Pinnacle Pioneers (AZ) | 04/09/2021 |
| 4 | Arcadia Titans (AZ) | #8 | 15 – 7 | #19 | Cactus Cobras (AZ) | 04/09/2021 |
| 5 | Catalina Foothills Falcons (AZ) | #11 | 16 – 6 | #17 | Chandler Pumas (AZ) | 04/09/2021 |
| 6 | Cactus Shadows Falcons (AZ) | #12 | 13 – 8 | #16 | Chandler Dogs (AZ) | 04/09/2021 |
