| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | North Carolina | #2 | vs | #4 | Virginia | 04/10/2021 |
| 2 | Notre Dame | #11 | vs | #1 | Duke | 04/10/2021 |
| 3 | Lehigh | #5 | vs | #13 | Navy | 04/10/2021 |
| 4 | Loyola | #12 | vs | #9 | Army | 04/10/2021 |
| 5 | Denver | #10 | vs | #16 | Villanova | 04/10/2021 |
| 6 | Penn State | #29 | vs | #6 | Rutgers | 04/10/2021 |
| 7 | Maryland | #3 | vs | #33 | Michigan | 04/10/2021 |
| 8 | UMBC | #20 | vs | #19 | UAlbany | 04/11/2021 |
| 9 | Delaware | #21 | vs | #18 | Drexel | 04/10/2021 |
| 10 | UMass | #22 | vs | #25 | Hofstra | 04/10/2021 |
| 11 | UMass | #22 | vs | #25 | Hofstra | 04/09/2021 |
| 12 | Johns Hopkins | #36 | vs | #15 | Ohio State | 04/10/2021 |
| 13 | Mercer | #40 | vs | #14 | Richmond | 04/11/2021 |
| 14 | Marquette | #48 | vs | #8 | Georgetown | 04/10/2021 |
| 15 | LIU | #42 | vs | #24 | Bryant | 04/10/2021 |
| 16 | Hobart | #31 | vs | #38 | Saint Joseph’s | 04/10/2021 |
| 17 | Towson | #23 | vs | #47 | Fairfield | 04/10/2021 |
| 18 | Providence | #35 | vs | #39 | St. John’s | 04/10/2021 |
| 19 | Jacksonville | #32 | vs | #43 | Air Force | 04/10/2021 |
| 20 | NJIT | #58 | vs | #17 | Stony Brook | 04/10/2021 |
| 21 | Colgate | #41 | vs | #37 | Boston University | 04/10/2021 |
| 22 | Robert Morris | #26 | vs | #54 | Cleveland State | 04/10/2021 |
| 23 | Binghamton | #30 | vs | #56 | Hartford | 04/10/2021 |
| 24 | UMass Lowell | #61 | vs | #28 | Vermont | 04/10/2021 |
| 25 | Mount St Mary’s | #46 | vs | #49 | Merrimack | 04/10/2021 |
