These were yesterday’s Best Games (and Results) in HS Girls Lacrosse in California. There were zero upsets.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Murrieta Mesa (CA) | #13 | 14 – 10 | #49 | Santiago (CA) | 04/07/2021 |
| 2 | Patrick Henry (CA) | #18 | 15 – 6 | #90 | Westview (CA) | 04/07/2021 |
| 3 | Mira Costa (CA) | #28 | 7 – 6 | #85 | Culver City (CA) | 04/07/2021 |
| 4 | Corona del Mar (CA) | #6 | 13 – 5 | #108 | Beckman (CA) | 04/07/2021 |
| 5 | King (CA) | #40 | 19 – 1 | #98 | Poly (CA) | 04/07/2021 |
| 6 | Rio Americano (CA) | #29 | 9 – 5 | #116 | Woodcreek (CA) | 04/07/2021 |
| 7 | Lick-Wilmerding (CA) | #39 | 20 – 12 | #140 | Urban (CA) | 04/07/2021 |
| 8 | Portola (CA) | #65 | 13 – 10 | #124 | Northwood (CA) | 04/07/2021 |
| 9 | Christian Brothers (CA) | #69 | 19 – 8 | #126 | Del Oro (CA) | 04/07/2021 |
| 10 | Woodbridge (CA) | #95 | 13 – 0 | #100 | Irvine (CA) | 04/07/2021 |
