Based on (1) the Best Teams playing the Best Teams and (2) the Best Teams being defined by their wins and losses in 2021, these are this weekend’s Best Games.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Benedictine (Kan.) | #8 | vs | #5 | St. Ambrose (Iowa) | 04/03/2021 |
| 2 | Indiana Tech | #2 | vs | #14 | Siena Heights (Mich.) | 04/03/2021 |
| 3 | Concordia (Mich.) | #4 | vs | #15 | Taylor (Ind.) | 04/03/2021 |
| 4 | Cumberlands (Ky.) | #7 | vs | #17 | SCAD Savannah (Ga.) | 04/02/2021 |
| 5 | Lawrence Tech (Mich.) | #23 | vs | #9 | Madonna (Mich.) | 04/03/2021 |
| 6 | Montreat (N.C.) | #33 | vs | #1 | Reinhardt (Ga.) | 04/03/2021 |
| 7 | Ottawa (Kan.) | #18 | vs | #22 | Clarke (Iowa) | 04/03/2021 |
| 8 | Saint Mary (Kan.) | #29 | vs | #11 | William Penn (Iowa) | 04/03/2021 |
| 9 | Point (Ga.) | #35 | vs | #19 | St. Andrews (N.C.) | 04/02/2021 |
| 10 | Mount Vernon Nazarene (Ohio) | #16 | vs | #0 | Oakland University | 04/03/2021 |
