Based on (1) the Best Teams playing the Best Teams and (2) the Best Teams being defined by their wins and losses in 2021, these are this weekend’s Best Games.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Salisbury | #4 | vs | #2 | Christopher Newport | 04/03/2021 |
| 2 | Lynchburg | #1 | vs | #8 | Washington and Lee | 04/03/2021 |
| 3 | Washington and Lee | #8 | vs | #1 | Lynchburg | 04/02/2021 |
| 4 | Christopher Newport | #2 | vs | #20 | Colorado College | 04/04/2021 |
| 5 | York | #6 | vs | #23 | Stevens | 04/03/2021 |
| 6 | Southern Virginia | #11 | vs | #20 | Colorado College | 04/02/2021 |
| 7 | Widener | #24 | vs | #47 | Arcadia | 04/03/2021 |
| 8 | Pfeiffer | #36 | vs | #51 | Greensboro | 04/03/2021 |
| 9 | Shenandoah | #55 | vs | #32 | Randolph-Macon | 04/03/2021 |
| 10 | Baldwin Wallace | #9 | vs | #83 | Mount Union | 04/03/2021 |
| 11 | St. Lawrence | #42 | vs | #57 | Skidmore | 04/03/2021 |
| 12 | Wittenberg | #92 | vs | #13 | Transylvania | 04/03/2021 |
| 13 | Nazareth | #110 | vs | #7 | Saint John Fisher | 04/03/2021 |
| 14 | Denison | #88 | vs | #40 | Ohio Wesleyan | 04/03/2021 |
| 15 | Mary Washington | #74 | vs | #54 | Saint Mary’s (Md) | 04/03/2021 |
| 16 | Mount Union | #83 | vs | #49 | Capital | 04/02/2021 |
| 17 | Roanoke | #10 | vs | #125 | Virginia Wesleyan | 04/03/2021 |
| 18 | St. Joseph (CT) | #98 | vs | #38 | Norwich | 04/03/2021 |
| 19 | Geneseo | #105 | vs | #31 | Cortland | 04/02/2021 |
| 20 | Delaware Valley | #16 | vs | #123 | Albright | 04/03/2021 |
| 21 | Otterbein | #78 | vs | #68 | Ohio Northern | 04/03/2021 |
| 22 | Franklin and Marshall | #50 | vs | #100 | Muhlenberg | 04/03/2021 |
| 23 | Hampden-Sydney | #5 | vs | #148 | Ferrum | 04/03/2021 |
| 24 | Moravian | #41 | vs | #114 | Susquehanna | 04/03/2021 |
| 25 | Montclair State | #66 | vs | #95 | Stockton | 04/03/2021 |
