Based on (1) the Best Teams playing the Best Teams and (2) the Best Teams being defined by their wins and losses in 2021, these are this weekend’s Best Games.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | North Carolina | #2 | vs | #1 | Syracuse | 04/03/2021 |
| 2 | Virginia | #6 | vs | #5 | Notre Dame | 04/03/2021 |
| 3 | Boston College | #4 | vs | #10 | Duke | 04/03/2021 |
| 4 | Cincinnati | #30 | vs | #18 | Temple | 04/04/2021 |
| 5 | Hofstra | #28 | vs | #20 | Drexel | 04/03/2021 |
| 6 | Cincinnati | #30 | vs | #18 | Temple | 04/02/2021 |
| 7 | Loyola | #11 | vs | #43 | Lehigh | 04/03/2021 |
| 8 | UC Davis | #42 | vs | #22 | Stanford | 04/04/2021 |
| 9 | Colorado | #45 | vs | #27 | Arizona State | 04/04/2021 |
| 10 | Vermont | #67 | vs | #8 | Stony Brook | 04/03/2021 |
| 11 | Towson | #26 | vs | #56 | High Point | 04/03/2021 |
| 12 | Colorado | #45 | vs | #37 | USC | 04/02/2021 |
| 13 | Virginia Tech | #49 | vs | #39 | Louisville | 04/03/2021 |
| 14 | William and Mary | #70 | vs | #19 | Elon | 04/03/2021 |
| 15 | Monmouth | #50 | vs | #40 | Fairfield | 04/03/2021 |
| 16 | Marist | #44 | vs | #47 | Niagara | 04/03/2021 |
| 17 | Marist | #44 | vs | #47 | Niagara | 04/02/2021 |
| 18 | Saint Joseph’s | #34 | vs | #58 | Duquesne | 04/03/2021 |
| 19 | Florida | #16 | vs | #82 | East Carolina | 04/03/2021 |
| 20 | Jacksonville | #9 | vs | #92 | Stetson | 04/03/2021 |
| 21 | Oregon | #80 | vs | #27 | Arizona State | 04/02/2021 |
| 22 | UC Davis | #42 | vs | #68 | California | 04/02/2021 |
| 23 | Vanderbilt | #17 | vs | #95 | Old Dominion | 04/03/2021 |
| 24 | VCU | #65 | vs | #48 | George Washington | 04/03/2021 |
| 25 | Oregon | #80 | vs | #37 | USC | 04/04/2021 |
