Based on (1) the Best Teams playing the Best Teams and (2) the Best Teams being defined by their wins and losses in 2021, these are this weekend’s Best Games.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Salisbury | #1 | vs | #7 | Christopher Newport | 04/03/2021 |
| 2 | Misericordia | #12 | vs | #11 | Stevenson | 04/03/2021 |
| 3 | Roanoke | #17 | vs | #6 | Mary Washington | 04/03/2021 |
| 4 | Stevens | #43 | vs | #3 | York | 04/03/2021 |
| 5 | Otterbein | #54 | vs | #9 | John Carroll | 04/03/2021 |
| 6 | Oglethorpe | #39 | vs | #27 | Rhodes | 04/03/2021 |
| 7 | Meredith | #15 | vs | #55 | Randolph-Macon | 04/02/2021 |
| 8 | RIT | #34 | vs | #40 | Skidmore | 04/03/2021 |
| 9 | Skidmore | #40 | vs | #34 | RIT | 04/02/2021 |
| 10 | Hope | #26 | vs | #60 | Albion | 04/03/2021 |
| 11 | St. John Fisher | #16 | vs | #74 | Sage | 04/03/2021 |
| 12 | Montclair State | #68 | vs | #32 | TCNJ | 04/03/2021 |
| 13 | Hood | #105 | vs | #4 | FDU-Florham | 04/03/2021 |
| 14 | Mount Union | #14 | vs | #96 | Ohio Northern | 04/03/2021 |
| 15 | Springfield College | #45 | vs | #88 | Wheaton | 04/03/2021 |
| 16 | Susquehanna | #62 | vs | #72 | Moravian | 04/03/2021 |
| 17 | Thiel | #49 | vs | #86 | Bethany | 04/03/2021 |
| 18 | Wooster | #118 | vs | #24 | DePauw | 04/03/2021 |
| 19 | Trine | #69 | vs | #75 | St. Mary’s (IN) | 04/03/2021 |
| 20 | Clarkson | #112 | vs | #37 | St. Lawrence | 04/03/2021 |
| 21 | St. Lawrence | #37 | vs | #112 | Clarkson | 04/02/2021 |
| 22 | Ohio Wesleyan | #146 | vs | #5 | Denison | 04/03/2021 |
| 23 | Carroll (WI) | #13 | vs | #142 | Carthage | 04/03/2021 |
| 24 | Drew | #36 | vs | #128 | Juniata | 04/03/2021 |
| 25 | St. Joseph’s (NY) | #76 | vs | #89 | Farmingdale State | 04/03/2021 |
