Based on (1) the Best Teams playing the Best Teams and (2) the Best Teams being defined by their wins and losses in 2021, these are this weekend’s Best Games.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Life (Ga.) | #2 | vs | #4 | Keiser (Fla.) | 04/02/2021 |
| 2 | Benedictine (Kan.) | #13 | vs | #7 | St. Ambrose (Iowa) | 04/03/2021 |
| 3 | Cleary (Mich.) (Mich.) | #27 | vs | #5 | Siena Heights (Mich.) | 04/03/2021 |
| 4 | Aquinas (Mich.) | #16 | vs | #26 | Madonna (Mich.) | 04/03/2021 |
| 5 | SCAD Savannah (Ga.) | #12 | vs | #31 | Brenau (Ga.) | 04/02/2021 |
| 6 | Bethel (Ind.) | #40 | vs | #6 | Concordia (Mich.) | 04/03/2021 |
| 7 | Ottawa (Kan.) | #11 | vs | #46 | Clarke (Iowa) | 04/03/2021 |
| 8 | Point (Ga.) | #43 | vs | #14 | Truett-McConnell (Ga.) | 04/02/2021 |
| 9 | Warren Wilson (N.C.) | #41 | vs | #18 | Montreat (N.C.) | 04/02/2021 |
| 10 | Missouri Valley | #37 | vs | #39 | Culver-Stockton (Mo.) | 04/03/2021 |
| 11 | Saint Mary (Kan.) | #49 | vs | #28 | William Penn (Iowa) | 04/03/2021 |
| 12 | Rochester (Mich.) | #0 | vs | #8 | Indiana Tech | 04/03/2021 |
| 13 | Marian (Ind.) | #24 | vs | #0 | Earlham College | 04/03/2021 |
