Based on (1) the Best Teams playing the Best Teams and (2) the Best Teams being defined by their wins and losses in 2021, these are this weekend’s Best Games.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | UIndy | #2 | vs | #43 | Lewis | 04/03/2021 |
| 2 | Wingate | #15 | vs | #35 | Newberry | 04/03/2021 |
| 3 | UVa-Wise | #44 | vs | #12 | Limestone | 04/03/2021 |
| 4 | Queens | #7 | vs | #61 | Lincoln Memorial | 04/03/2021 |
| 5 | Mount Olive | #13 | vs | #89 | Converse | 04/03/2021 |
| 6 | Grand Valley State | #18 | vs | #85 | Concordia-St. Paul | 04/03/2021 |
| 7 | Adams State | #54 | vs | #53 | Westminster (UT) | 04/03/2021 |
| 8 | Colorado St.-Pueblo | #59 | vs | #48 | UC-Colo. Springs | 04/03/2021 |
| 9 | Young Harris | #74 | vs | #38 | Lenoir-Rhyne | 04/03/2021 |
| 10 | Frostburg State | #41 | vs | #84 | Charleston (WV) | 04/03/2021 |
| 11 | Ursuline | #83 | vs | #49 | Walsh University | 04/03/2021 |
| 12 | Coker | #90 | vs | #58 | Tusculum | 04/03/2021 |
| 13 | Rockhurst | #77 | vs | #79 | Missouri Western | 04/02/2021 |
| 14 | Chowan | #87 | vs | #70 | North Greenville | 04/03/2021 |
| 15 | Lees-McRae | #75 | vs | #82 | Southern Wesleyan | 04/03/2021 |
| 16 | Mars Hill | #78 | vs | #88 | Catawba | 04/03/2021 |
| 17 | Lander | #55 | vs | #0 | Shorter | 04/03/2021 |
