Based on (1) the Best Teams playing the Best Teams and (2) the Best Teams being defined by their wins and losses in 2021, these are this weekend’s Best Games.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | UIndy | #7 | vs | #9 | Maryville | 04/03/2021 |
| 2 | Wingate | #6 | vs | #10 | Newberry | 04/03/2021 |
| 3 | Mercyhurst | #4 | vs | #15 | Chestnut Hill | 04/03/2021 |
| 4 | Mount Olive | #3 | vs | #42 | North Greenville | 04/03/2021 |
| 5 | Lander | #22 | vs | #27 | Montevallo | 04/03/2021 |
| 6 | Mercyhurst | #4 | vs | #46 | Walsh | 04/03/2021 |
| 7 | Westminster | #30 | vs | #29 | Colorado Mesa | 04/03/2021 |
| 8 | Lindenwood | #8 | vs | #52 | Davenport | 04/03/2021 |
| 9 | Coker | #28 | vs | #34 | Tusculum | 04/02/2021 |
| 10 | Mars Hill | #57 | vs | #20 | Catawba | 04/03/2021 |
| 11 | Queens | #14 | vs | #63 | Lincoln Memorial | 04/03/2021 |
| 12 | Adelphi | #24 | vs | #54 | Assumption | 04/03/2021 |
| 13 | Roberts Wesleyan | #32 | vs | #53 | Molloy | 04/03/2021 |
| 14 | Barton | #38 | vs | #66 | Lees-McRae | 04/03/2021 |
| 15 | Lewis | #50 | vs | #56 | Quincy | 04/03/2021 |
| 16 | Shorter | #67 | vs | #64 | Alabama Huntsville | 04/03/2021 |
| 17 | Palm Beach Atlantic | #51 | vs | #0 | Embry-Riddle | 04/04/2021 |
| 19 | Adams State | #0 | vs | #0 | CSU Pueblo | 04/03/2021 |
