Based on (1) the Best Teams playing the Best Teams and (2) the Best Teams being defined by their wins and losses in 2021, these are this weekend’s Best Games.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Lehigh | #10 | vs | #7 | Army | 04/03/2021 |
| 2 | Virginia | #4 | vs | #13 | Richmond | 04/03/2021 |
| 3 | Ohio State | #14 | vs | #6 | Rutgers | 04/03/2021 |
| 4 | Syracuse | #5 | vs | #20 | Notre Dame | 04/03/2021 |
| 5 | Navy | #11 | vs | #18 | Loyola | 04/03/2021 |
| 6 | Maryland | #2 | vs | #27 | Penn State | 04/03/2021 |
| 7 | Drexel | #26 | vs | #19 | UMass | 04/03/2021 |
| 8 | St. John’s | #39 | vs | #8 | Georgetown | 04/03/2021 |
| 9 | UMBC | #25 | vs | #22 | Vermont | 04/03/2021 |
| 10 | Villanova | #21 | vs | #30 | Providence | 04/03/2021 |
| 11 | Denver | #9 | vs | #48 | Marquette | 04/03/2021 |
| 12 | Jacksonville | #17 | vs | #40 | Robert Morris | 04/03/2021 |
| 13 | Bryant | #16 | vs | #42 | Hobart | 04/03/2021 |
| 14 | Hofstra | #28 | vs | #31 | Towson | 04/03/2021 |
| 15 | Johns Hopkins | #29 | vs | #38 | Michigan | 04/04/2021 |
| 16 | Delaware | #24 | vs | #45 | Fairfield | 04/02/2021 |
| 17 | Hartford | #59 | vs | #15 | Stony Brook | 04/03/2021 |
| 18 | UAlbany | #12 | vs | #62 | UMass Lowell | 04/02/2021 |
| 19 | Air Force | #33 | vs | #47 | Mercer | 04/03/2021 |
| 20 | Boston University | #23 | vs | #57 | Utah | 04/03/2021 |
| 21 | Merrimack | #50 | vs | #32 | LIU | 04/03/2021 |
| 22 | Monmouth | #37 | vs | #51 | Quinnipiac | 04/03/2021 |
| 23 | Binghamton | #34 | vs | #54 | NJIT | 04/03/2021 |
| 24 | Bucknell | #43 | vs | #52 | Colgate | 04/03/2021 |
| 25 | High Point | #35 | vs | #60 | Bellarmine | 04/03/2021 |
