Weekend’s Best Games
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Columbia (Mo.) | #3 | 12 – 8 | #5 | St. Ambrose (Iowa) | 03/21/2021 |
| 2 | Columbia (Mo.) | #3 | 26 – 1 | #13 | Clarke (Iowa) | 03/19/2021 |
| 3 | Indiana Tech | #2 | 16 – 5 | #20 | Lawrence Tech (Mich.) | 03/20/2021 |
| 4 | Concordia (Mich.) | #6 | 10 – 8 | #18 | Lourdes (Ohio) | 03/19/2021 |
| 5 | Madonna (Mich.) | #10 | 13 – 5 | #17 | Taylor (Ind.) | 03/19/2021 |
| 6 | William Penn (Iowa) | #19 | 16 – 2 | #13 | Clarke (Iowa) | 03/20/2021 |
| 7 | Benedictine (Kan.) | #7 | 24 – 0 | #32 | Morningside (Iowa) | 03/20/2021 |
| 8 | Aquinas (Mich.) | #16 | 21 – 5 | #23 | Michigan-Dearborn | 03/20/2021 |
| 9 | SCAD Savannah (Ga.) | #15 | 10 – 9 | #26 | Webber International (Fla.) | 03/19/2021 |
| 10 | Missouri Baptist | #11 | 18 – 11 | #31 | Missouri Valley | 03/20/2021 |
| 11 | Tennessee Wesleyan | #12 | 16 – 7 | #33 | Montreat (N.C.) | 03/20/2021 |
| 12 | SCAD Savannah (Ga.) | #15 | 27 – 5 | #34 | Point (Ga.) | 03/20/2021 |
Weekend’s Best Upsets
None.
Best Upcoming Games
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Cumberlands (Ky.) | #9 | vs | #12 | Tennessee Wesleyan | 03/23/2021 |
| 2 | William Penn (Iowa) | #19 | vs | #7 | Benedictine (Kan.) | 03/24/2021 |
| 3 | Mount Vernon Nazarene (Ohio) | #22 | vs | #6 | Concordia (Mich.) | 03/24/2021 |
| 4 | Michigan-Dearborn | #23 | vs | #10 | Madonna (Mich.) | 03/24/2021 |
| 5 | Reinhardt (Ga.) | #1 | vs | #34 | Point (Ga.) | 03/23/2021 |
| 6 | Lawrence Tech (Mich.) | #20 | vs | #17 | Taylor (Ind.) | 03/24/2021 |
| 7 | Lourdes (Ohio) | #18 | vs | #0 | Siena Heights (Mich.) | 03/24/2021 |
