Weekend’s Best Games
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Virginia | #6 | 14 – 11 | #7 | Duke | 03/21/2021 |
| 2 | Duke | #7 | 17 – 8 | #6 | Virginia | 03/19/2021 |
| 3 | Penn State | #9 | 13 – 12 | #12 | Michigan | 03/21/2021 |
| 4 | Northwestern | #3 | 21 – 7 | #18 | Rutgers | 03/21/2021 |
| 5 | Michigan | #12 | 12 – 9 | #9 | Penn State | 03/19/2021 |
| 6 | Northwestern | #3 | 22 – 10 | #18 | Rutgers | 03/19/2021 |
| 7 | Boston College | #5 | 19 – 7 | #21 | Hofstra | 03/20/2021 |
| 8 | North Carolina | #1 | 15 – 5 | #30 | James Madison | 03/21/2021 |
| 9 | Florida | #25 | 14 – 7 | #14 | Temple | 03/21/2021 |
| 10 | Stony Brook | #10 | 18 – 11 | #29 | UAlbany | 03/20/2021 |
| 11 | Florida | #25 | 15 – 9 | #14 | Temple | 03/19/2021 |
| 12 | Notre Dame | #11 | 15 – 10 | #32 | Louisville | 03/21/2021 |
| 13 | Vanderbilt | #15 | 16 – 14 | #35 | Cincinnati | 03/21/2021 |
| 14 | Vanderbilt | #15 | 10 – 8 | #35 | Cincinnati | 03/19/2021 |
| 15 | Towson | #20 | 14 – 12 | #31 | Saint Joseph’s | 03/20/2021 |
| 16 | Maryland | #8 | 11 – 5 | #51 | Ohio State | 03/21/2021 |
| 17 | Maryland | #8 | 11 – 5 | #51 | Ohio State | 03/19/2021 |
| 18 | Notre Dame | #11 | 19 – 5 | #50 | Liberty | 03/19/2021 |
| 19 | Jacksonville | #4 | 10 – 9 | #58 | Virginia Tech | 03/20/2021 |
| 20 | Stanford | #19 | 10 – 9 | #45 | Colorado | 03/20/2021 |
| 21 | Arizona State | #27 | 20 – 9 | #38 | USC | 03/19/2021 |
| 22 | Arizona State | #27 | 19 – 14 | #44 | UC Davis | 03/21/2021 |
| 23 | Georgetown | #23 | 18 – 8 | #59 | Villanova | 03/21/2021 |
| 24 | Georgetown | #23 | 19 – 11 | #59 | Villanova | 03/19/2021 |
| 25 | Elon | #16 | 13 – 9 | #67 | Furman | 03/20/2021 |
Weekend’s Best Upsets
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | New Hampshire | #79 | 14 – 13 | #57 | UMBC | 03/20/2021 |
| 2 | Old Dominion | #101 | 13 – 12 | #88 | East Carolina | 03/21/2021 |
| 3 | Florida | #25 | 15 – 9 | #14 | Temple | 03/19/2021 |
| 4 | Florida | #25 | 14 – 7 | #14 | Temple | 03/21/2021 |
| 5 | Michigan | #12 | 12 – 9 | #9 | Penn State | 03/19/2021 |
| 6 | Duke | #7 | 17 – 8 | #6 | Virginia | 03/19/2021 |
| 7 | Oregon | #83 | 14 – 9 | #82 | California | 03/20/2021 |
Best Upcoming Games
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Vermont | #52 | vs | #28 | UMass | 03/24/2021 |
| 2 | Wagner | #49 | vs | #47 | Mount St Mary’s | 03/24/2021 |
| 3 | Oregon | #83 | vs | #19 | Stanford | 03/22/2021 |
| 4 | High Point | #61 | vs | #50 | Liberty | 03/24/2021 |
| 5 | Colorado | #45 | vs | #82 | California | 03/22/2021 |
| 6 | Coastal Carolina | #43 | vs | #99 | Campbell | 03/24/2021 |
| 7 | Furman | #67 | vs | #90 | Winthrop | 03/24/2021 |
| 8 | LIU | #55 | vs | #106 | Saint Francis | 03/24/2021 |
| 9 | Virginia Tech | #58 | vs | #103 | Radford | 03/23/2021 |
| 10 | Kent State | #95 | vs | #73 | Presbyterian | 03/22/2021 |
| 11 | Central Connecticut | #110 | vs | #64 | Bryant | 03/24/2021 |
| 12 | Akron | #111 | vs | #73 | Presbyterian | 03/23/2021 |
| 13 | Sacred Heart | #108 | vs | #87 | Merrimack | 03/24/2021 |
| 14 | American | #97 | vs | #105 | Longwood | 03/24/2021 |
