Weekend’s Best Games
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Mercy | #5 | 10 – 9 | #17 | Roberts Wesleyan | 03/20/2021 |
| 2 | Mercyhurst | #2 | 17 – 12 | #21 | Seton Hill | 03/20/2021 |
| 3 | Lenoir-Rhyne | #1 | 15 – 7 | #24 | Queens | 03/20/2021 |
| 4 | Lindenwood | #6 | 7 – 3 | #33 | Rockhurst | 03/20/2021 |
| 5 | Limestone | #8 | 16 – 5 | #34 | Tusculum | 03/20/2021 |
| 6 | Maryville | #4 | 15 – 11 | #45 | Lewis | 03/20/2021 |
| 7 | Le Moyne | #15 | 12 – 7 | #35 | Adelphi | 03/20/2021 |
| 8 | Catawba | #12 | 18 – 10 | #39 | Anderson (SC) | 03/20/2021 |
| 9 | Belmont Abbey | #13 | 14 – 11 | #43 | Barton | 03/20/2021 |
| 10 | Tampa | #20 | 24 – 8 | #36 | Saint Leo | 03/19/2021 |
| 11 | Mount Olive | #3 | 20 – 4 | #55 | Chowan | 03/20/2021 |
| 12 | Wingate | #7 | 26 – 6 | #52 | Mars Hill | 03/20/2021 |
| 13 | Pace | #22 | 21 – 7 | #38 | Saint Rose | 03/20/2021 |
| 14 | UIndy | #10 | 17 – 4 | #51 | Quincy | 03/20/2021 |
| 15 | Lynn | #25 | 19 – 5 | #40 | Palm Beach Atlantic | 03/20/2021 |
| 16 | Lander | #14 | 15 – 14 | #57 | Alabama Huntsville | 03/20/2021 |
| 17 | Southern New Hampshire | #28 | 16 – 15 | #46 | Franklin Pierce | 03/20/2021 |
| 18 | Saint Michael’s | #32 | 14 – 3 | #48 | AIC | 03/20/2021 |
| 19 | Emmanuel (Ga.) | #23 | 18 – 11 | #60 | Lees-McRae | 03/20/2021 |
| 20 | Montevallo | #27 | 15 – 6 | #58 | Shorter | 03/19/2021 |
| 21 | Lake Erie | #47 | 16 – 7 | #41 | Wilmington | 03/21/2021 |
| 22 | Dominican (NY) | #37 | 13 – 8 | #56 | Felician | 03/20/2021 |
| 23 | Walsh | #42 | 27 – 3 | #54 | Alderson-Broaddus | 03/20/2021 |
Weekend’s Best Upsets
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Lake Erie | #47 | 16 – 7 | #41 | Wilmington | 03/21/2021 |
Best Upcoming Games
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Newberry | #9 | vs | #1 | Lenoir-Rhyne | 03/24/2021 |
| 2 | Catawba | #12 | vs | #7 | Wingate | 03/24/2021 |
| 3 | Queens | #24 | vs | #30 | Coker | 03/24/2021 |
| 4 | Wheeling | #59 | vs | #2 | Mercyhurst | 03/22/2021 |
| 5 | Emmanuel (Ga.) | #23 | vs | #44 | North Greenville | 03/24/2021 |
| 6 | Frostburg | #19 | vs | #54 | Alderson-Broaddus | 03/24/2021 |
| 7 | Lees-McRae | #60 | vs | #13 | Belmont Abbey | 03/24/2021 |
| 8 | Tusculum | #34 | vs | #39 | Anderson (SC) | 03/24/2021 |
| 9 | Caldwell | #29 | vs | #49 | Molloy | 03/24/2021 |
| 10 | Chowan | #55 | vs | #43 | Barton | 03/24/2021 |
