All the higher-seeded teams won in the Quarterfinals including #1 Marvin Ridge over #6 Charlotte Catholic.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Marvin Ridge (NC) | #1 | 5 – 4 | #6 | Charlotte Catholic (NC) | 03/22/2021 |
| 2 | Weddington (NC) | #4 | 13 – 7 | #10 | Northern Guilford (NC) | 03/22/2021 |
| 3 | Cardinal Gibbons (NC) | #2 | 18 – 6 | #13 | Fuquay – Varina (NC) | 03/22/2021 |
| 4 | Lake Norman (NC) | #7 | 16 – 11 | #8 | Ardrey Kell (NC) | 03/22/2021 |
| 5 | Hough (NC) | #3 | 16 – 12 | #14 | Northwest Guilford (NC) | 03/22/2021 |
| 6 | Holly Springs (NC) | #20 | 17 – 8 | #42 | Ashley (NC) | 03/22/2021 |
| 7 | East Chapel Hill (NC) | #27 | 15 – 12 | #37 | Orange (NC) | 03/22/2021 |
| 8 | Topsail (NC) | #49 | 13 – 8 | #73 | West Brunswick (NC) | 03/22/2021 |
On Wednesday, there are four semifinal games including a #1 Marvin Ridge vs. #4 Weddington match-up.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Marvin Ridge (NC) | #1 | vs | #4 | Weddington (NC) | 03/24/2021 |
| 2 | Hough (NC) | #3 | vs | #7 | Lake Norman (NC) | 03/24/2021 |
| 3 | Cardinal Gibbons (NC) | #2 | vs | #20 | Holly Springs (NC) | 03/24/2021 |
| 4 | Topsail (NC) | #49 | vs | #27 | East Chapel Hill (NC) | 03/24/2021 |
