The higher-seeded teams won in the Quarterfinals, including #2 Charlotte Catholic over #3 Myers Park, except… #17 Wake Forest upset #11 Holly Springs.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Charlotte Catholic (NC) | #2 | 19 – 13 | #3 | Myers Park (NC) | 03/22/2021 |
| 2 | Weddington (NC) | #1 | 15 – 4 | #5 | Northwest Guilford (NC) | 03/22/2021 |
| 3 | East Chapel Hill (NC) | #6 | 19 – 12 | #10 | Cardinal Gibbons (NC) | 03/22/2021 |
| 4 | Wake Forest (NC) | #17 | 5 – 4 | #11 | Holly Springs (NC) | 03/22/2021 |
Setting up the two Wednesday semifinal games where, some would argue, one of the Semifinal games looks like the Finals.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Weddington (NC) | #1 | vs | #2 | Charlotte Catholic (NC) | 03/24/2021 |
| 2 | Wake Forest (NC) | #17 | vs | #6 | East Chapel Hill (NC) | 03/24/2021 |
