Weekend’s Best Games
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | UIndy | #1 | 9 – 7 | #22 | Grand Valley State | 03/21/2021 |
| 2 | Roberts Wesleyan | #4 | 23 – 15 | #29 | St. Thomas Aquinas | 03/21/2021 |
| 3 | Roberts Wesleyan | #4 | 11 – 10 | #33 | Mercy | 03/20/2021 |
| 4 | Queens | #3 | 21 – 5 | #37 | Lenoir-Rhyne | 03/20/2021 |
| 5 | Lindenwood | #2 | 18 – 13 | #40 | Colorado Mesa | 03/21/2021 |
| 6 | Seton Hill | #8 | 16 – 6 | #35 | Slippery Rock | 03/20/2021 |
| 7 | Limestone | #5 | 14 – 4 | #52 | Lincoln Memorial | 03/21/2021 |
| 8 | Le Moyne | #18 | 13 – 6 | #41 | New Haven | 03/20/2021 |
| 9 | West Chester | #13 | 20 – 5 | #48 | Millersville | 03/20/2021 |
| 10 | Florida Southern | #20 | 17 – 3 | #43 | Florida Tech | 03/20/2021 |
| 11 | Tampa | #19 | 10 – 9 | #44 | Saint Leo | 03/20/2021 |
| 12 | Newberry | #16 | 15 – 13 | #54 | Tusculum | 03/20/2021 |
| 13 | Mount Olive | #6 | 17 – 7 | #66 | Young Harris | 03/21/2021 |
| 14 | Shepherd | #17 | 13 – 9 | #57 | Shippensburg | 03/20/2021 |
| 15 | Lee | #21 | 15 – 10 | #59 | Montevallo | 03/21/2021 |
| 16 | Wingate | #12 | 17 – 3 | #73 | Mars Hill | 03/20/2021 |
| 17 | Frostburg State | #24 | 19 – 11 | #62 | Wilmington | 03/20/2021 |
| 18 | Belmont Abbey | #11 | 22 – 2 | #76 | Southern Wesleyan | 03/20/2021 |
| 19 | Bloomsburg | #15 | 16 – 3 | #72 | Kutztown | 03/20/2021 |
| 20 | Assumption | #27 | 15 – 11 | #61 | Stonehill | 03/20/2021 |
| 21 | Concordia-St. Paul | #36 | 18 – 5 | #56 | Ashland | 03/21/2021 |
| 22 | Concordia-St. Paul | #36 | 16 – 6 | #56 | Ashland | 03/19/2021 |
| 23 | St. Thomas Aquinas | #29 | 16 – 6 | #65 | Holy Family | 03/19/2021 |
| 24 | Indiana (PA) | #47 | 12 – 11 | #51 | Lock Haven | 03/20/2021 |
| 25 | Regis (CO) | #31 | 16 – 7 | #71 | Rockhurst | 03/20/2021 |
Weekend’s Best Upsets
None.
Best Upcoming Games
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Barton | #30 | vs | #11 | Belmont Abbey | 03/24/2021 |
| 2 | UIndy | #1 | vs | #40 | Colorado Mesa | 03/23/2021 |
| 3 | Lees-McRae | #45 | vs | #6 | Mount Olive | 03/24/2021 |
| 4 | Newberry | #16 | vs | #37 | Lenoir-Rhyne | 03/24/2021 |
| 5 | Bloomsburg | #15 | vs | #57 | Shippensburg | 03/23/2021 |
| 6 | North Greenville | #58 | vs | #19 | Tampa | 03/23/2021 |
| 7 | Queens | #3 | vs | #77 | Coker | 03/24/2021 |
| 8 | St. Thomas Aquinas | #29 | vs | #53 | Chestnut Hill | 03/24/2021 |
| 9 | Catawba | #79 | vs | #12 | Wingate | 03/24/2021 |
| 10 | Tusculum | #54 | vs | #49 | UVa-Wise | 03/24/2021 |
| 11 | Assumption | #27 | vs | #0 | Saint Anselm | 03/24/2021 |
| 12 | Charleston (WV) | #69 | vs | #0 | Davis & Elkins | 03/24/2021 |
