This weekend, there are numerous games and several are quality games. These games, in order, are:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | St. Ambrose (Iowa) | #4 | vs | #5 | Columbia (Mo.) | 03/21/2021 |
| 2 | Clarke (Iowa) | #10 | vs | #5 | Columbia (Mo.) | 03/19/2021 |
| 3 | Concordia (Mich.) | #8 | vs | #13 | Lourdes (Ohio) | 03/20/2021 |
| 4 | Taylor (Ind.) | #16 | vs | #11 | Madonna (Mich.) | 03/20/2021 |
| 5 | Clarke (Iowa) | #10 | vs | #23 | William Penn (Iowa) | 03/20/2021 |
| 6 | Benedictine (Kan.) | #9 | vs | #27 | Midland (Neb.) | 03/21/2021 |
| 7 | Missouri Baptist | #12 | vs | #24 | Missouri Valley | 03/20/2021 |
| 8 | Benedictine (Kan.) | #9 | vs | #28 | Morningside (Iowa) | 03/20/2021 |
| 9 | Tennessee Wesleyan | #15 | vs | #30 | Montreat (N.C.) | 03/20/2021 |
| 10 | Webber International (Fla.) | #19 | vs | #0 | SCAD Savannah (Ga.) | 03/19/2021 |
| 11 | Point (Ga.) | #31 | vs | #0 | SCAD Savannah (Ga.) | 03/20/2021 |
