This weekend, there are numerous games and several are quality games. These games, in order, are:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Christopher Newport | #1 | vs | #2 | Lynchburg | 03/20/2021 |
| 2 | Salisbury | #12 | vs | #18 | Colorado College | 03/21/2021 |
| 3 | Centre | #19 | vs | #20 | Berry | 03/20/2021 |
| 4 | RIT | #8 | vs | #33 | Cortland | 03/20/2021 |
| 5 | Saint Mary’s (Md) | #23 | vs | #18 | Colorado College | 03/19/2021 |
| 6 | Ohio Northern | #28 | vs | #14 | Baldwin Wallace | 03/20/2021 |
| 7 | Roanoke | #16 | vs | #39 | Washington and Lee | 03/20/2021 |
| 8 | Mary Washington | #32 | vs | #27 | Washington | 03/20/2021 |
| 9 | Hope | #13 | vs | #48 | Adrian | 03/20/2021 |
| 10 | John Carroll | #21 | vs | #45 | Mount Union | 03/20/2021 |
| 11 | Widener | #62 | vs | #4 | Lebanon Valley | 03/20/2021 |
| 12 | Illinois Wesleyan | #6 | vs | #60 | Southwestern | 03/19/2021 |
| 13 | Concordia-Wisconsin | #63 | vs | #15 | North Central (Ill.) | 03/20/2021 |
| 14 | Stevenson | #10 | vs | #72 | Delaware Valley | 03/20/2021 |
| 15 | Randolph-Macon | #25 | vs | #61 | Guilford | 03/20/2021 |
| 16 | Bridgewater | #67 | vs | #22 | Hampden-Sydney | 03/20/2021 |
| 17 | Aurora | #86 | vs | #7 | Carthage | 03/20/2021 |
| 18 | Marian | #56 | vs | #43 | Augustana | 03/20/2021 |
| 19 | Benedictine | #46 | vs | #60 | Southwestern | 03/21/2021 |
| 20 | Albright | #53 | vs | #58 | Eastern | 03/20/2021 |
| 21 | Virginia Wesleyan | #76 | vs | #35 | Shenandoah | 03/20/2021 |
| 22 | Pfeiffer | #34 | vs | #82 | Methodist | 03/21/2021 |
| 23 | Heidelberg | #94 | vs | #31 | Capital | 03/20/2021 |
| 24 | Hendrix | #52 | vs | #77 | Rhodes | 03/21/2021 |
| 25 | La Roche | #44 | vs | #88 | Mt St Joseph | 03/20/2021 |
