This weekend, there are numerous games and several are quality games. These games, in order, are:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Virginia | #4 | vs | #10 | Duke | 03/21/2021 |
| 2 | Virginia | #4 | vs | #10 | Duke | 03/19/2021 |
| 3 | Rutgers | #16 | vs | #3 | Northwestern | 03/21/2021 |
| 4 | Rutgers | #16 | vs | #3 | Northwestern | 03/19/2021 |
| 5 | Hofstra | #18 | vs | #6 | Boston College | 03/20/2021 |
| 6 | Cincinnati | #13 | vs | #15 | Vanderbilt | 03/21/2021 |
| 7 | Cincinnati | #13 | vs | #15 | Vanderbilt | 03/19/2021 |
| 8 | Stony Brook | #7 | vs | #22 | UAlbany | 03/20/2021 |
| 9 | Temple | #8 | vs | #35 | Florida | 03/21/2021 |
| 10 | Saint Joseph’s | #24 | vs | #19 | Towson | 03/20/2021 |
| 11 | Temple | #8 | vs | #35 | Florida | 03/19/2021 |
| 12 | Penn State | #17 | vs | #29 | Michigan | 03/21/2021 |
| 13 | Penn State | #17 | vs | #29 | Michigan | 03/19/2021 |
| 14 | Maryland | #5 | vs | #49 | Ohio State | 03/21/2021 |
| 15 | Maryland | #5 | vs | #49 | Ohio State | 03/19/2021 |
| 16 | USC | #25 | vs | #33 | Arizona State | 03/19/2021 |
| 17 | Arizona State | #33 | vs | #31 | UC Davis | 03/21/2021 |
| 18 | Virginia Tech | #54 | vs | #12 | Jacksonville | 03/20/2021 |
| 19 | Colorado | #40 | vs | #34 | Stanford | 03/20/2021 |
| 20 | Notre Dame | #27 | vs | #48 | Liberty | 03/19/2021 |
| 21 | Elon | #14 | vs | #67 | Furman | 03/20/2021 |
| 22 | Bucknell | #73 | vs | #9 | Loyola | 03/20/2021 |
| 23 | Drexel | #11 | vs | #75 | La Salle | 03/20/2021 |
| 24 | Marquette | #64 | vs | #28 | UConn | 03/21/2021 |
| 25 | Marquette | #64 | vs | #28 | UConn | 03/19/2021 |
