This weekend, there are numerous games and several are quality games. These games, in order, are:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Queens | #20 | vs | #2 | Lenoir-Rhyne | 03/20/2021 |
| 2 | Seton Hill | #19 | vs | #6 | Mercyhurst | 03/20/2021 |
| 3 | Limestone | #7 | vs | #25 | Tusculum | 03/20/2021 |
| 4 | Maryville | #3 | vs | #32 | Lewis | 03/20/2021 |
| 5 | Rockhurst | #26 | vs | #9 | Lindenwood | 03/20/2021 |
| 6 | Anderson (SC) | #28 | vs | #11 | Catawba | 03/20/2021 |
| 7 | Barton | #31 | vs | #13 | Belmont Abbey | 03/20/2021 |
| 8 | Mount Olive | #1 | vs | #44 | Chowan | 03/20/2021 |
| 9 | Wingate | #4 | vs | #41 | Mars Hill | 03/20/2021 |
| 10 | UIndy | #12 | vs | #40 | Quincy | 03/20/2021 |
| 11 | vs | #17 | Frostburg | 03/20/2021 | ||
| 12 | Lander | #18 | vs | #45 | Alabama Huntsville | 03/20/2021 |
| 13 | Dominican (NY) | #30 | vs | #35 | Felician | 03/20/2021 |
| 14 | Shorter | #43 | vs | #23 | Montevallo | 03/19/2021 |
| 15 | Emmanuel (Ga.) | #21 | vs | #46 | Lees-McRae | 03/20/2021 |
| 16 | Walsh | #34 | vs | #38 | Alderson-Broaddus | 03/20/2021 |
| 17 | Lincoln Memorial | #48 | vs | #27 | Coker | 03/20/2021 |
| 18 | Queens | #20 | vs | #0 | Embry-Riddle | 03/21/2021 |
| 19 | Wilmington | #0 | vs | #39 | Lake Erie | 03/20/2021 |
| 22 | Adelphi | #0 | vs | #0 | Southern New Hampshire | 03/20/2021 |
| 23 | Assumption | #0 | vs | #0 | Franklin Pierce | 03/20/2021 |
