This weekend, there are numerous games and several are quality games. These games, in order, are:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Tusculum | #29 | vs | #4 | Limestone | 03/20/2021 |
| 2 | Queens | #3 | vs | #31 | Lenoir-Rhyne | 03/20/2021 |
| 3 | Newberry | #14 | vs | #21 | Barton | 03/20/2021 |
| 4 | Mount Olive | #6 | vs | #50 | Young Harris | 03/21/2021 |
| 5 | Lee | #27 | vs | #34 | Montevallo | 03/20/2021 |
| 6 | Wingate | #10 | vs | #60 | Mars Hill | 03/20/2021 |
| 7 | Belmont Abbey | #9 | vs | #63 | Southern Wesleyan | 03/20/2021 |
| 8 | Bloomsburg | #25 | vs | #59 | Kutztown | 03/20/2021 |
| 9 | Colorado St.-Pueblo | #46 | vs | #43 | Missouri Western | 03/21/2021 |
| 10 | Rockhurst | #56 | vs | #35 | Regis (CO) | 03/20/2021 |
| 11 | Findlay | #52 | vs | #51 | Ursuline | 03/19/2021 |
| 12 | Converse | #61 | vs | #44 | Lees-McRae | 03/20/2021 |
| 13 | Tiffin | #62 | vs | #51 | Ursuline | 03/21/2021 |
| 14 | UVa-Wise | #53 | vs | #65 | Catawba | 03/20/2021 |
| 15 | Lindenwood | #2 | vs | #0 | Colorado Mesa | 03/21/2021 |
| 16 | Concordia-St. Paul | #33 | vs | #0 | Ashland | 03/21/2021 |
| 17 | Concordia-St. Paul | #33 | vs | #0 | Ashland | 03/19/2021 |
| 18 | Assumption | #0 | vs | #47 | Stonehill | 03/20/2021 |
