This weekend, there are numerous games and several are quality games. These games, in order, are:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Salisbury | #1 | vs | #29 | TCNJ | 03/20/2021 |
| 2 | Otterbein | #19 | vs | #13 | Mount Union | 03/20/2021 |
| 3 | Hood | #27 | vs | #16 | York | 03/20/2021 |
| 4 | Kalamazoo | #46 | vs | #6 | Hope | 03/20/2021 |
| 5 | St. Mary’s (MD) | #10 | vs | #48 | Randolph-Macon | 03/20/2021 |
| 6 | Centre | #41 | vs | #31 | Oglethorpe | 03/20/2021 |
| 7 | Albion | #39 | vs | #37 | St. Mary’s (IN) | 03/21/2021 |
| 8 | Misericordia | #15 | vs | #61 | Stevens | 03/20/2021 |
| 9 | Christopher Newport | #9 | vs | #73 | Shenandoah | 03/20/2021 |
| 10 | Sewanee | #67 | vs | #20 | Rhodes | 03/21/2021 |
| 11 | Sewanee | #67 | vs | #20 | Rhodes | 03/20/2021 |
| 12 | Hamline | #88 | vs | #7 | Illinois Wesleyan | 03/20/2021 |
| 13 | Averett | #83 | vs | #12 | Methodist | 03/20/2021 |
| 14 | John Carroll | #2 | vs | #99 | Muskingum | 03/20/2021 |
| 15 | Mary Washington | #64 | vs | #38 | Washington & Lee | 03/20/2021 |
| 16 | N. Carolina Wesleyan | #104 | vs | #4 | Meredith | 03/19/2021 |
| 17 | Capital | #17 | vs | #98 | Baldwin Wallace | 03/20/2021 |
| 18 | Augsburg | #111 | vs | #7 | Illinois Wesleyan | 03/21/2021 |
| 19 | Wilkes | #56 | vs | #65 | King’s | 03/20/2021 |
| 20 | Concordia-Chicago | #30 | vs | #94 | Wartburg | 03/21/2021 |
| 21 | Augustana | #81 | vs | #45 | Southwestern | 03/21/2021 |
| 22 | Delaware Valley | #110 | vs | #21 | Stevenson | 03/20/2021 |
| 23 | DePauw | #40 | vs | #97 | Transylvania | 03/20/2021 |
| 24 | Carthage | #70 | vs | #89 | Concordia-Wisconsin | 03/20/2021 |
| 25 | Calvin | #106 | vs | #55 | Trine | 03/20/2021 |
