This weekend, there are numerous games and… These are the Best:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Washington & Lee | #3 | vs | #15 | FDU-Florham | 05/09/2021 |
| 2 | Tufts | #4 | vs | #31 | Cabrini | 05/08/2021 |
| 3 | William Smith | #12 | vs | #35 | Meredith | 05/08/2021 |
| 4 | Babson | #40 | vs | #14 | TCNJ | 05/09/2021 |
| 5 | Westfield State | #19 | vs | #37 | Roger Williams | 05/09/2021 |
| 6 | Salisbury | #1 | vs | #63 | Morrisville State | 05/08/2021 |
| 7 | Western Connecticut | #18 | vs | #48 | Johnson & Wales (Providence) | 05/08/2021 |
| 8 | Washington & Jefferson | #55 | vs | #46 | Farmingdale State | 05/08/2021 |
| 9 | St. John Fisher | #6 | vs | #105 | Cazenovia | 05/08/2021 |
| 10 | Illinois Wesleyan | #60 | vs | #53 | George Fox | 05/08/2021 |
| 11 | Ithaca | #20 | vs | #99 | Notre Dame (MD) | 05/09/2021 |
| 12 | John Carroll | #43 | vs | #88 | UW-River Falls | 05/08/2021 |
| 13 | Catholic (DC) | #10 | vs | #123 | Becker | 05/08/2021 |
| 14 | Denison | #27 | vs | #109 | St. Mary’s (IN) | 05/09/2021 |
| 15 | Cortland | #2 | vs | #137 | Transylvania | 05/08/2021 |
| 16 | Carroll (WI) | #59 | vs | #114 | Aurora | 05/09/2021 |
| 17 | Chicago | #70 | vs | #202 | Hamline | 05/08/2021 |
