This weekend, there are numerous games and… These are the Best:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | RIT | #1 | vs | #6 | St. Lawrence | 05/08/2021 |
| 2 | Salisbury | #2 | vs | #7 | Christopher Newport | 05/08/2021 |
| 3 | Stevenson | #4 | vs | #10 | York | 05/08/2021 |
| 4 | Williams | #13 | vs | #8 | Tufts | 05/08/2021 |
| 5 | Washington and Lee | #16 | vs | #5 | Lynchburg | 05/08/2021 |
| 6 | Cortland | #25 | vs | #27 | Geneseo | 05/07/2021 |
| 7 | Stevens | #17 | vs | #37 | Misericordia | 05/08/2021 |
| 8 | Coast Guard | #30 | vs | #29 | Babson | 05/08/2021 |
| 9 | Baldwin Wallace | #38 | vs | #22 | John Carroll | 05/08/2021 |
| 10 | Catholic | #23 | vs | #49 | Elizabethtown | 05/08/2021 |
| 11 | Denison | #35 | vs | #40 | Kenyon | 05/08/2021 |
| 12 | Illinois Wesleyan | #36 | vs | #39 | North Central (Ill.) | 05/08/2021 |
| 13 | Stockton | #54 | vs | #31 | Kean | 05/08/2021 |
| 14 | Endicott | #46 | vs | #45 | Western New England | 05/08/2021 |
| 15 | Saint John Fisher | #9 | vs | #101 | Nazareth | 05/08/2021 |
| 16 | SUNY Maritime | #56 | vs | #58 | Farmingdale | 05/08/2021 |
| 17 | Cabrini | #24 | vs | #92 | Neumann | 05/08/2021 |
| 18 | Albion | #63 | vs | #66 | Hope | 05/07/2021 |
| 19 | UMass-Boston | #53 | vs | #93 | Western Connecticut | 05/08/2021 |
| 20 | Lasell | #70 | vs | #90 | Norwich | 05/08/2021 |
| 21 | Pfeiffer | #65 | vs | #106 | Piedmont | 05/08/2021 |
| 22 | Transylvania | #28 | vs | #145 | Hanover | 05/08/2021 |
| 23 | Saint John Fisher | #9 | vs | #181 | Keuka | 05/08/2021 |
| 24 | Grove City | #99 | vs | #178 | Westminster (Pa.) | 05/08/2021 |
| 25 | SUNY Poly | #88 | vs | #222 | Husson | 05/08/2021 |
