These were yesterday’s Best Games. There were no upsets.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Salisbury | #1 | 16 – 7 | #24 | St. Mary’s (MD) | 04/28/2021 |
| 2 | Ithaca | #22 | 20 – 8 | #31 | St. Lawrence | 04/28/2021 |
| 3 | Catholic (DC) | #12 | 18 – 6 | #46 | Susquehanna | 04/28/2021 |
| 4 | Christopher Newport | #23 | 12 – 9 | #48 | Mary Washington | 04/28/2021 |
| 5 | Scranton | #18 | 19 – 7 | #57 | Moravian | 04/28/2021 |
| 6 | William Smith | #11 | 19 – 4 | #69 | Union | 04/28/2021 |
| 7 | Carroll (WI) | #36 | 11 – 5 | #59 | Illinois Wesleyan | 04/28/2021 |
| 8 | Cabrini | #28 | 23 – 6 | #73 | Gwynedd-Mercy | 04/28/2021 |
| 9 | Montclair State | #2 | 20 – 10 | #99 | Stockton | 04/28/2021 |
| 10 | Marymount | #26 | 16 – 8 | #82 | Marywood | 04/28/2021 |
| 11 | Lynchburg | #38 | 28 – 4 | #87 | Guilford | 04/28/2021 |
| 12 | TCNJ | #17 | 19 – 12 | #113 | Rowan | 04/28/2021 |
| 13 | Endicott | #27 | 25 – 2 | #104 | Gordon | 04/28/2021 |
| 14 | Wooster | #30 | 17 – 16 | #108 | Oberlin | 04/28/2021 |
| 15 | Johnson & Wales (Providence) | #45 | 15 – 13 | #97 | Lasell | 04/28/2021 |
| 16 | Shenandoah | #51 | 17 – 11 | #91 | Randolph-Macon | 04/28/2021 |
| 17 | Allegheny | #60 | 14 – 12 | #131 | Ohio Wesleyan | 04/28/2021 |
| 18 | Franklin & Marshall | #16 | 20 – 2 | #207 | Muhlenberg | 04/28/2021 |
| 19 | Concordia-Chicago | #63 | 17 – 5 | #162 | Concordia-Wisconsin | 04/28/2021 |
| 20 | Washington & Jefferson | #53 | 17 – 12 | #182 | Franciscan | 04/28/2021 |
| 21 | Hope | #75 | 19 – 9 | #167 | Calvin | 04/28/2021 |
| 22 | Farmingdale State | #42 | 19 – 12 | #209 | Manhattanville | 04/28/2021 |
| 23 | Chicago | #71 | 18 – 6 | #196 | Carthage | 04/28/2021 |
| 24 | Emmanuel (MA) | #41 | 20 – 1 | #226 | Anna Maria | 04/28/2021 |
| 25 | US Merchant Marine Academy | #110 | 12 – 11 | #170 | St. Joseph’s (NY) | 04/28/2021 |
