These were yesterday’s Best Games. There were no upsets.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Ursinus | #17 | 13 – 12 | #29 | Muhlenberg | 04/28/2021 |
| 2 | St. Lawrence | #11 | 14 – 8 | #54 | Clarkson | 04/28/2021 |
| 3 | Saint John Fisher | #7 | 18 – 13 | #60 | Alfred | 04/28/2021 |
| 4 | Catholic | #22 | 16 – 10 | #52 | Elizabethtown | 04/28/2021 |
| 5 | Union | #13 | 15 – 8 | #88 | RPI | 04/28/2021 |
| 6 | Denison | #43 | 22 – 4 | #61 | Wittenberg | 04/28/2021 |
| 7 | Misericordia | #35 | 16 – 12 | #73 | DeSales | 04/28/2021 |
| 8 | Washington and Lee | #16 | 17 – 10 | #108 | Guilford | 04/28/2021 |
| 9 | Ithaca | #14 | 20 – 7 | #115 | Skidmore | 04/28/2021 |
| 10 | Hampden-Sydney | #9 | 25 – 14 | #129 | Virginia Wesleyan | 04/28/2021 |
| 11 | Endicott | #48 | 21 – 4 | #107 | Curry | 04/28/2021 |
| 12 | Kean | #44 | 14 – 2 | #113 | Montclair State | 04/28/2021 |
| 13 | North Central (Ill.) | #39 | 13 – 8 | #126 | Augustana | 04/28/2021 |
| 14 | Roger Williams | #59 | 17 – 6 | #114 | Wentworth | 04/28/2021 |
| 15 | Transylvania | #28 | 17 – 5 | #147 | Hanover | 04/28/2021 |
| 16 | Norwich | #87 | 17 – 13 | #92 | New England College | 04/28/2021 |
| 17 | Stockton | #50 | 29 – 1 | #148 | Bryn Athyn | 04/28/2021 |
| 18 | Western New England | #42 | 18 – 9 | #157 | Nichols | 04/28/2021 |
| 19 | Moravian | #77 | 16 – 5 | #164 | Drew | 04/28/2021 |
| 20 | Bridgewater | #45 | 27 – 1 | #198 | Randolph | 04/28/2021 |
| 21 | SUNY Poly | #85 | 7 – 5 | #187 | SUNY Delhi | 04/28/2021 |
| 22 | Marymount | #137 | 16 – 6 | #143 | Immaculata | 04/28/2021 |
| 23 | Elmhurst | #89 | 24 – 3 | #194 | Carroll (Wisc.) | 04/28/2021 |
| 24 | Mount Union | #102 | 17 – 4 | #210 | Heidelberg | 04/28/2021 |
| 25 | Eastern Connecticut | #131 | 11 – 2 | #209 | Castleton | 04/28/2021 |
