Best Upsets are marked with an asterisks*. Some teams are under-rated due to having limited quality wins.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Nassau | #2 | 17 – 6 | #5 | Genesee | 04/23/2021 |
| 2* | CCBC Essex | #4 | 13 – 6 | #3 | Howard (MD) | 04/23/2021 |
| 3 | Harford | #1 | 34 – 0 | #12 | Southern Maryland | 04/23/2021 |
| 4 | Anne Arundel | #6 | 19 – 6 | #9 | Mercer County | 04/23/2021 |
| 5 | Howard (MD) | #3 | 31 – 3 | #12 | Southern Maryland | 04/23/2021 |
| 6 | Mercer County | #9 | 18 – 10 | #15 | Sussex County | 04/23/2021 |
