Yesterday, there were no upsets but there were 17 Best Games.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Salisbury | #1 | 17 – 2 | #31 | Mary Washington | 04/20/2021 |
| 2 | Christopher Newport | #23 | 15 – 8 | #40 | Meredith | 04/20/2021 |
| 3 | Roanoke | #15 | 26 – 3 | #194 | Randolph | 04/20/2021 |
| 4 | Misericordia | #42 | 18 – 6 | #176 | Wilkes | 04/20/2021 |
| 5 | Southern Maine | #100 | 10 – 7 | #123 | Plymouth State | 04/20/2021 |
| 6 | Farmingdale State | #35 | 19 – 8 | #218 | Manhattanville | 04/20/2021 |
| 7 | Rowan | #144 | 24 – 8 | #114 | Stockton | 04/20/2021 |
| 8 | Moravian | #53 | 18 – 4 | #217 | Juniata | 04/20/2021 |
| 9 | St. John Fisher | #45 | 23 – 1 | #230 | Houghton | 04/20/2021 |
| 10 | Eastern Connecticut | #60 | 24 – 6 | #232 | Rhode Island College | 04/20/2021 |
| 11 | Allegheny | #119 | 14 – 11 | #191 | Kenyon | 04/20/2021 |
| 12 | Methodist | #109 | 13 – 7 | #209 | Pfeiffer | 04/20/2021 |
| 13 | US Merchant Marine Academy | #155 | 13 – 4 | #199 | Purchase | 04/20/2021 |
| 14 | Becker | #116 | 22 – 5 | #247 | Mitchell | 04/20/2021 |
| 15 | Hanover | #158 | 13 – 6 | #213 | Anderson | 04/20/2021 |
| 16 | Concordia-Wisconsin | #152 | 21 – 4 | #238 | Marian (Wi.) | 04/20/2021 |
| 17 | Franciscan | #183 | 19 – 5 | #252 | Waynesburg | 04/20/2021 |
