Yesterday, there were no upsets but there were 12 Best Games.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Christopher Newport | #4 | 14 – 13 | #11 | Washington and Lee | 04/20/2021 |
| 2 | Gettysburg | #5 | 16 – 8 | #58 | Washington | 04/20/2021 |
| 3 | Ohio Wesleyan | #21 | 14 – 10 | #133 | Wooster | 04/20/2021 |
| 4 | Lasell | #67 | 15 – 5 | #95 | Norwich | 04/20/2021 |
| 5 | UMass-Boston | #61 | 10 – 8 | #138 | Eastern Connecticut | 04/20/2021 |
| 6 | Albion | #59 | 23 – 9 | #177 | Adrian | 04/20/2021 |
| 7 | Keene State | #43 | 24 – 4 | #208 | Castleton | 04/20/2021 |
| 8 | Hope | #63 | 21 – 9 | #201 | Kalamazoo | 04/20/2021 |
| 9 | Kean | #77 | 22 – 0 | #215 | Keystone | 04/20/2021 |
| 10 | Montclair State | #89 | 22 – 3 | #206 | Centenary (NJ) | 04/20/2021 |
| 11 | MSOE | #148 | 21 – 4 | #224 | Edgewood | 04/20/2021 |
| 12 | St. Joseph (CT) | #170 | 12 – 5 | #210 | Emmanuel | 04/20/2021 |
