In order, these are today’s 25 Best Games.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Salisbury | #1 | vs | #31 | Mary Washington | 04/20/2021 |
| 2 | Meredith | #34 | vs | #26 | Christopher Newport | 04/20/2021 |
| 3 | Western New England | #8 | vs | #78 | Salve Regina | 04/20/2021 |
| 4 | Concordia-Chicago | #41 | vs | #101 | Aurora | 04/20/2021 |
| 5 | Skidmore | #57 | vs | #85 | Union | 04/20/2021 |
| 6 | UW-River Falls | #76 | vs | #98 | UW-Eau Claire | 04/20/2021 |
| 7 | TCNJ | #17 | vs | #166 | Rutgers-Camden | 04/20/2021 |
| 8 | Randolph | #192 | vs | #15 | Roanoke | 04/20/2021 |
| 9 | Misericordia | #42 | vs | #173 | Wilkes | 04/20/2021 |
| 10 | Manhattanville | #203 | vs | #36 | Farmingdale State | 04/20/2021 |
| 11 | Chicago | #54 | vs | #205 | Augustana | 04/20/2021 |
| 12 | Nazareth | #38 | vs | #228 | Alfred | 04/20/2021 |
| 13 | Susquehanna | #88 | vs | #180 | Elizabethtown | 04/20/2021 |
| 14 | Moravian | #53 | vs | #215 | Juniata | 04/20/2021 |
| 15 | Rhode Island College | #211 | vs | #60 | Eastern Connecticut | 04/20/2021 |
| 16 | St. John Fisher | #45 | vs | #230 | Houghton | 04/20/2021 |
| 17 | Plymouth State | #109 | vs | #167 | Southern Maine | 04/20/2021 |
| 18 | Northwestern-St. Paul | #50 | vs | #232 | Augsburg | 04/20/2021 |
| 19 | Castleton State | #189 | vs | #100 | Keene State | 04/20/2021 |
| 20 | Washington & Jefferson | #64 | vs | #251 | Waynesburg | 04/20/2021 |
| 21 | Stockton | #107 | vs | #210 | Rowan | 04/20/2021 |
| 22 | Methodist | #133 | vs | #208 | Pfeiffer | 04/20/2021 |
| 23 | Allegheny | #181 | vs | #169 | Kenyon | 04/20/2021 |
| 24 | Mitchell | #246 | vs | #115 | Becker | 04/20/2021 |
| 25 | Fredonia | #155 | vs | #241 | Wells | 04/20/2021 |
