Numerous Best Games this weekend (below), 1 Upset, and 1 Best Upsets (which are marked with an asterisks).
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Clemson | #3 | 13 – 10 | #6 | Liberty | 04/17/2021 |
| 2 | Brigham Young | #2 | 12 – 3 | #19 | Arizona | 04/17/2021 |
| 3* | Minnesota | #20 | 22 – 14 | #5 | Missouri State | 04/17/2021 |
| 4 | Missouri State | #5 | 19 – 16 | #22 | Tennessee | 04/16/2021 |
| 5 | Georgia Tech | #1 | 14 – 9 | #28 | Auburn | 04/17/2021 |
| 6 | Virginia Tech | #13 | 17 – 14 | #20 | Minnesota | 04/16/2021 |
| 7 | Florida | #12 | 6 – 0 | #24 | LSU | 04/17/2021 |
| 8 | St. Thomas | #8 | 12 – 4 | #31 | St. John’s | 04/16/2021 |
| 9 | Florida | #12 | 7 – 6 | #29 | Florida State | 04/16/2021 |
| 10 | Minnesota | #20 | 14 – 6 | #22 | Tennessee | 04/17/2021 |
| 11 | Texas Christian | #11 | 15 – 7 | #33 | Kansas | 04/17/2021 |
| 12 | Montana | #15 | 16 – 8 | #38 | North Dakota State | 04/17/2021 |
