All teams are ranked according to their Best Wins and Worst Losses in 2021. In other words, if an objectively pretty good team only has 2 wins, they will have a lower rank than they objectively should have.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Le Moyne | #1 | vs | #39 | Adelphi | 04/17/2021 |
| 2 | Shippensburg | #28 | vs | #15 | Bloomsburg | 04/17/2021 |
| 3 | Mount Olive | #18 | vs | #27 | Belmont Abbey | 04/17/2021 |
| 4 | Lindenwood | #6 | vs | #78 | Rockhurst | 04/18/2021 |
| 5 | UIndy | #2 | vs | #91 | Quincy | 04/18/2021 |
| 6 | Assumption | #16 | vs | #79 | Saint Michael’s | 04/17/2021 |
| 7 | UIndy | #2 | vs | #97 | Maryville | 04/16/2021 |
| 8 | Wingate | #19 | vs | #81 | Tusculum | 04/17/2021 |
| 9 | McKendree | #23 | vs | #78 | Rockhurst | 04/16/2021 |
| 10 | Concordia-St. Paul | #89 | vs | #26 | Davenport | 04/18/2021 |
| 11 | Concordia-St. Paul | #89 | vs | #26 | Davenport | 04/16/2021 |
| 12 | Colorado St.-Pueblo | #74 | vs | #43 | Colorado Mesa | 04/16/2021 |
| 13 | Montevallo | #46 | vs | #71 | Lander | 04/16/2021 |
| 14 | Regis (CO) | #31 | vs | #86 | Adams State | 04/16/2021 |
| 15 | Alabama-Huntsville | #52 | vs | #71 | Lander | 04/18/2021 |
| 16 | Charleston (WV) | #93 | vs | #36 | Frostburg State | 04/17/2021 |
| 17 | UVa-Wise | #42 | vs | #87 | Coker | 04/17/2021 |
| 18 | UC-Colo. Springs | #45 | vs | #86 | Adams State | 04/18/2021 |
| 19 | Newberry | #62 | vs | #69 | Lincoln Memorial | 04/17/2021 |
| 20 | Lenoir-Rhyne | #60 | vs | #72 | Mars Hill | 04/17/2021 |
| 21 | Chestnut Hill | #85 | vs | #54 | Post University | 04/17/2021 |
| 22 | Converse | #96 | vs | #44 | Barton | 04/17/2021 |
| 23 | Walsh University | #41 | vs | #100 | Ursuline | 04/16/2021 |
| 24 | Lees-McRae | #84 | vs | #76 | North Greenville | 04/16/2021 |
| 25 | Lewis | #75 | vs | #91 | Quincy | 04/16/2021 |
