Numerous Best Games this weekend. No upsets.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Georgia Tech | #1 | 19 – 10 | #24 | Florida State | 04/09/2021 |
| 2 | Missouri State | #5 | 16 – 5 | #30 | Illinois | 04/11/2021 |
| 3 | Virginia Tech | #17 | 25 – 6 | #18 | Tennessee | 04/11/2021 |
| 4 | Texas Christian | #8 | 15 – 9 | #28 | Texas | 04/11/2021 |
| 5 | Missouri State | #5 | 14 – 9 | #31 | North Dakota State | 04/10/2021 |
| 6 | Oregon | #14 | 16 – 10 | #23 | Oregon State | 04/11/2021 |
| 7 | Missouri State | #5 | 19 – 4 | #32 | Minn.-Duluth | 04/09/2021 |
| 8 | Boise State | #4 | 13 – 8 | #37 | Utah State | 04/09/2021 |
