| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | St. Mary’s (MD) | #14 | vs | #9 | Meredith | 04/11/2021 |
| 2 | Christopher Newport | #24 | vs | #12 | Mary Washington | 04/10/2021 |
| 3 | St. Mary’s (MD) | #14 | vs | #32 | Southern Virginia | 04/09/2021 |
| 4 | Messiah | #4 | vs | #44 | Widener | 04/10/2021 |
| 5 | Carroll (WI) | #19 | vs | #43 | UW-River Falls | 04/10/2021 |
| 6 | Lebanon Valley | #51 | vs | #18 | York | 04/10/2021 |
| 7 | Shenandoah | #47 | vs | #23 | Roanoke | 04/10/2021 |
| 8 | Neumann | #50 | vs | #22 | Marymount | 04/10/2021 |
| 9 | Drew | #25 | vs | #63 | Susquehanna | 04/10/2021 |
| 10 | St. Lawrence | #42 | vs | #71 | Rochester | 04/10/2021 |
| 11 | Rochester | #71 | vs | #42 | St. Lawrence | 04/09/2021 |
| 12 | Sage | #87 | vs | #38 | Nazareth | 04/10/2021 |
| 13 | Capital | #60 | vs | #66 | Otterbein | 04/10/2021 |
| 14 | TCNJ | #40 | vs | #90 | Kean | 04/10/2021 |
| 15 | Averett | #125 | vs | #9 | Meredith | 04/10/2021 |
| 16 | Wilkes | #133 | vs | #8 | FDU-Florham | 04/10/2021 |
| 17 | Rhodes | #36 | vs | #108 | Berry | 04/11/2021 |
| 18 | Rhodes | #36 | vs | #108 | Berry | 04/10/2021 |
| 19 | Mount St. Mary | #93 | vs | #52 | Farmingdale State | 04/09/2021 |
| 20 | Concordia-Chicago | #37 | vs | #109 | Concordia-Wisconsin | 04/10/2021 |
| 21 | Trine | #114 | vs | #33 | Hope | 04/10/2021 |
| 22 | Rutgers-Camden | #140 | vs | #10 | Montclair State | 04/10/2021 |
| 23 | Stevens | #45 | vs | #120 | Lycoming | 04/10/2021 |
| 24 | Transylvania | #135 | vs | #30 | DePauw | 04/09/2021 |
| 25 | Elizabethtown | #154 | vs | #16 | Scranton | 04/10/2021 |
