| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Bloomsburg | #15 | vs | #25 | Shepherd | 04/10/2021 |
| 2 | Queens | #6 | vs | #50 | UVa-Wise | 04/10/2021 |
| 3 | Colorado Mesa | #41 | vs | #28 | Regis (CO) | 04/09/2021 |
| 4 | Rockhurst | #79 | vs | #2 | UIndy | 04/11/2021 |
| 5 | Colorado Mesa | #41 | vs | #43 | UC-Colo. Springs | 04/11/2021 |
| 6 | Missouri Western | #83 | vs | #2 | UIndy | 04/09/2021 |
| 7 | Lee | #31 | vs | #55 | Alabama-Huntsville | 04/11/2021 |
| 8 | Stonehill | #70 | vs | #27 | Assumption | 04/10/2021 |
| 9 | Southern Wesleyan | #85 | vs | #16 | Mount Olive | 04/10/2021 |
| 10 | Coker | #89 | vs | #14 | Limestone | 04/10/2021 |
| 11 | Chowan | #92 | vs | #24 | Belmont Abbey | 04/10/2021 |
| 12 | Lincoln Memorial | #65 | vs | #51 | Lenoir-Rhyne | 04/10/2021 |
| 13 | North Greenville | #64 | vs | #52 | Barton | 04/10/2021 |
| 14 | Rockhurst | #79 | vs | #45 | Lewis | 04/09/2021 |
| 15 | Missouri Western | #83 | vs | #45 | Lewis | 04/11/2021 |
| 16 | Alabama-Huntsville | #55 | vs | #74 | Young Harris | 04/09/2021 |
| 17 | Mars Hill | #81 | vs | #54 | Newberry | 04/10/2021 |
| 18 | Montevallo | #62 | vs | #74 | Young Harris | 04/11/2021 |
| 19 | Adams State | #75 | vs | #80 | Colorado St.-Pueblo | 04/09/2021 |
| 20 | Tusculum | #82 | vs | #93 | Catawba | 04/11/2021 |
| 21 | Lees-McRae | #84 | vs | #96 | Erskine | 04/10/2021 |
| 22 | Alderson-Broaddus | #95 | vs | #88 | Charleston (WV) | 04/11/2021 |
| 23 | Chestnut Hill | #68 | vs | #0 | Felician | 04/10/2021 |
