| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Lynchburg | #3 | vs | #11 | Roanoke | 04/10/2021 |
| 2 | Hampden-Sydney | #5 | vs | #19 | Randolph-Macon | 04/10/2021 |
| 3 | Stevenson | #15 | vs | #16 | Eastern | 04/10/2021 |
| 4 | Washington | #36 | vs | #1 | Salisbury | 04/10/2021 |
| 5 | Misericordia | #22 | vs | #21 | Delaware Valley | 04/10/2021 |
| 6 | York | #7 | vs | #38 | Lebanon Valley | 04/10/2021 |
| 7 | Illinois Wesleyan | #17 | vs | #35 | Carthage | 04/10/2021 |
| 8 | Ithaca | #25 | vs | #37 | Clarkson | 04/10/2021 |
| 9 | Albion | #46 | vs | #18 | Transylvania | 04/10/2021 |
| 10 | RIT | #2 | vs | #73 | Skidmore | 04/10/2021 |
| 11 | Rhodes | #51 | vs | #27 | Centre | 04/11/2021 |
| 12 | Saint Mary’s (Md) | #67 | vs | #13 | Southern Virginia | 04/10/2021 |
| 13 | Saint John Fisher | #6 | vs | #75 | Oneonta | 04/10/2021 |
| 14 | Christopher Newport | #4 | vs | #85 | Mary Washington | 04/10/2021 |
| 15 | Alfred | #47 | vs | #45 | Utica | 04/10/2021 |
| 16 | Catholic | #66 | vs | #33 | Moravian | 04/10/2021 |
| 17 | Lasell | #61 | vs | #44 | Norwich | 04/10/2021 |
| 18 | Gettysburg | #53 | vs | #59 | Ursinus | 04/10/2021 |
| 19 | Capital | #58 | vs | #65 | Otterbein | 04/10/2021 |
| 20 | Massachusetts Maritime | #91 | vs | #34 | Bridgewater | 04/09/2021 |
| 21 | Scranton | #43 | vs | #84 | Elizabethtown | 04/10/2021 |
| 22 | Eastern Connecticut | #50 | vs | #81 | Keene State | 04/10/2021 |
| 23 | Salve Regina | #87 | vs | #52 | Roger Williams | 04/10/2021 |
| 24 | Guilford | #109 | vs | #34 | Bridgewater | 04/10/2021 |
| 25 | Franklin and Marshall | #23 | vs | #121 | McDaniel | 04/10/2021 |
