| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Salisbury | #1 | vs | #14 | Southern Virginia | 03/26/2021 |
| 2 | Lynchburg | #15 | vs | #3 | Washington & Lee | 03/27/2021 |
| 3 | Carroll (WI) | #10 | vs | #11 | Illinois Wesleyan | 03/27/2021 |
| 4 | Capital | #19 | vs | #20 | Mount Union | 03/27/2021 |
| 5 | Mary Washington | #52 | vs | #5 | Christopher Newport | 03/27/2021 |
| 6 | Washington College | #38 | vs | #21 | St. Mary’s (MD) | 03/27/2021 |
| 7 | Methodist | #55 | vs | #12 | Meredith | 03/27/2021 |
| 8 | Rhodes | #32 | vs | #42 | Centre | 03/28/2021 |
| 9 | Rhodes | #32 | vs | #42 | Centre | 03/27/2021 |
| 10 | John Carroll | #7 | vs | #72 | Ohio Northern | 03/27/2021 |
| 11 | St. Mary’s (IN) | #61 | vs | #18 | Hope | 03/27/2021 |
| 12 | Albright | #58 | vs | #23 | Stevenson | 03/27/2021 |
| 13 | York | #6 | vs | #97 | DeSales | 03/27/2021 |
| 14 | UW-La Crosse | #41 | vs | #82 | Carthage | 03/27/2021 |
| 15 | Oglethorpe | #48 | vs | #106 | Birmingham-Southern | 03/27/2021 |
| 16 | Denison | #17 | vs | #140 | Wittenberg | 03/27/2021 |
| 17 | UW-La Crosse | #41 | vs | #125 | Edgewood | 03/26/2021 |
| 18 | Randolph-Macon | #63 | vs | #104 | Bridgewater | 03/27/2021 |
| 19 | Wilkes | #88 | vs | #85 | Stevens | 03/27/2021 |
| 20 | Kalamazoo | #76 | vs | #101 | Calvin | 03/27/2021 |
| 21 | UW-River Falls | #99 | vs | #82 | Carthage | 03/28/2021 |
| 22 | Sewanee | #103 | vs | #80 | Berry | 03/28/2021 |
| 23 | Sewanee | #103 | vs | #80 | Berry | 03/27/2021 |
| 24 | Alma | #145 | vs | #46 | Albion | 03/27/2021 |
| 25 | Adrian | #136 | vs | #64 | Trine | 03/27/2021 |
