All things CoronaVirus

[tech37]

Tech's Reuters reference https://www.reuters.com/business/health ... 021-06-09/ describes a new, experimental drug from Merck, "Molnupiravir". This is an RNA modifying drug. It is not the same has "Ivermectin". Different chemistry.

Molnupiravir is similar to Remdesivir in that, as a nucleotide derivative, replaces a building block in the virus' genetic code which inhibits replication of the virus.

Ivermectin's theorised virostatic mechanisms of action are different and do not target the genetic sequence:

Inhibit viral RdRP (RNA dependent RNA Polymerase) - prevent viral replication.

Inhibit 3CLPro (3 Chymotrypsin-like Protease) - prevent formation of viral proteins out of polyprotein.

Inhibit binding of viral proteins to importin nucleus transporters.

Inhibit binding of virus spike protein - computer models show binding affinity to the receptor binding domain of the S protein.

So what? How does different chemistry change the argument? Looking for your usual straw man I suppose.

[jhu72]

Mr. conspiracy theory. ^^^

[tech37]

Mr. conspiracy theory. ^^^

That's the best you can do? What an uncreative bore.

[jhu72]

... perhaps boring, just not tin foil hat wearing.

[Typical Lax Dad]

Merck a manufacturer of Ivermectin press release 2/4/21:

KENILWORTH, N.J., Feb. 4, 2021 – Merck (NYSE: MRK), known as MSD outside the United States and Canada, today affirmed its position regarding use of ivermectin during the COVID-19 pandemic. Company scientists continue to carefully examine the findings of all available and emerging studies of ivermectin for the treatment of COVID-19 for evidence of efficacy and safety. It is important to note that, to-date, our analysis has identified:

No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies;
No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and;
A concerning lack of safety data in the majority of studies.
We do not believe that the data available support the safety and efficacy of ivermectin beyond the doses and populations indicated in the regulatory agency-approved prescribing information.

Well of course! 1. The politicians and medical establishment are trying to get as many people vaccinated as possible. Any evidence that an available therapeutic (prescribed off-label or not) shows prophylactic or treatment promise could slow or discourage vaccination.
2. Merck (and many others) stand to profit handsomely by developing a new therapeutic specifically for Covid... perhaps even you jhu72? See the posted 1.2 billion advance article.

Merck is shooting for 2021 approval for their new drug. BS, IMO. We won't see any new approved therapeutics until every last person is vaccinated and/or the last of the variants are done. Don't hold your breath.

https://ir.alexion.com/news-releases/ne ... ultomirisr

Were not expecting to make money on this effort.

This is how it turned out:

https://www.fiercepharma.com/pharma/ale ... ing-severe

[tech37]

... perhaps boring, just not tin foil hat wearing.

again... unimaginative, lame, worn-out, banal, hackneyed, tedious, trite...

[jhu72]

... and right!

[tech37]

... and right!

How many shares of Merck do you and your Dr. wife own?

[Farfromgeneva]

The selling of Ivermectin.

BULLSH!T story you posted from WaPo.

https://www.wsj.com/articles/fda-iverme ... 1627482393

behind paywall...

The Food and Drug Administration claims to follow the science. So why is it attacking
ivermectin, a medication it certified in 1996?
Earlier this year the agency put out a special warning that “you should not use ivermectin
to treat or prevent COVID-19.” The FDA’s statement included words and phrases such as
“serious harm,” “hospitalized,” “dangerous,” “very dangerous,” “seizures,” “coma and
even death” and “highly toxic.” Any reader would think the FDA was warning against
poison pills. In fact, the drug is FDA-approved as a safe and effective antiparasitic.
Ivermectin was developed and marketed by Merck & Co. while one of us (Mr. Hooper)
worked there years ago. William C. Campbell and Satoshi Omura won the 2015 Nobel Prize
for Physiology or Medicine for discovering and developing avermectin, which Mr.
Campbell and associates modified to create ivermectin.
Ivermectin is on the World Health Organization’s List of Essential Medicines. Merck has
donated four billion doses to prevent river blindness and other diseases in Africa and
other places where parasites are common. A group of 10 doctors who call themselves the
Front Line Covid-19 Critical Care Alliance have said ivermectin is “one of the safest, lowcost, and widely available drugs in the history of medicine.”
Ivermectin fights 21 viruses, including SARS-CoV-2, the cause of Covid-19. A single dose
OPINION | COMMENTARY
Why Is the FDA Attacking a Safe, Effective
Drug?
Ivermectin is a promising Covid treatment and prophylaxis, but the agency is denigrating it.
By David R. Henderson and Charles L. Hooper
July 28, 2021 12:34 pm ET
Ivermectin in Buenos Aires, Jan. 26.
PHOTO: ROBERTO ALMEIDA AVELEDO/ZUMA PRESS
reduced the viral load of SARS-CoV-2 in cells by 99.8% in 24 hours and 99.98% in 48 hours,
according to a June 2020 study published in the journal Antiviral Research.
Some 70 clinical trials are evaluating the use of ivermectin for treating Covid-19. The
statistically significant evidence suggests that it is safe and works for both treating and
preventing the disease.
In 115 patients with Covid-19 who received a single dose of ivermectin, none developed
pneumonia or cardiovascular complications, while 11.4% of those in the control group did.
Fewer ivermectin patients developed respiratory distress (2.6% vs. 15.8%); fewer required
oxygen (9.6% vs. 45.9%); fewer required antibiotics (15.7% vs. 60.2%); and fewer entered
intensive care (0.1% vs. 8.3%). Ivermectin-treated patients tested negative faster, in four
days instead of 15, and stayed in the hospital nine days on average instead of 15.
Ivermectin patients experienced 13.3% mortality compared with 24.5% in the control
group.
Moreover, the drug can help prevent Covid-19. One 2020 article in Biochemical and
Biophysical Research Communications looked at what happened after the drug was given
to family members of confirmed Covid-19 patients. Less than 8% became infected, versus
58.4% of those untreated. Among 200 healthcare workers and others at high risk of
exposure, only 2% of those given ivermectin developed Covid-19. But 10% of the control
group did.
Despite the FDA’s claims, ivermectin is safe at approved doses. Out of four billion doses
administered since 1998, there have been only 28 cases of serious neurological adverse
events, according to an article published this year in the American Journal of
Therapeutics. The same study found that ivermectin has been used safely in pregnant
women, children and infants.
If the FDA were driven by science and evidence, it would give an emergency-use
authorization for ivermectin for Covid-19. Instead, the FDA asserts without evidence that
ivermectin is dangerous.
At the bottom of the FDA’s warning against ivermectin is this statement: “Meanwhile,
effective ways to limit the spread of COVID-19 continue to be to wear your mask, stay at
least 6 feet from others who don’t live with you, wash hands frequently, and avoid
crowds.” Is this based on the kinds of double-blind studies that the FDA requires for drug
approvals? No.
Mr. Henderson, a research fellow with the Hoover Institution at Stanford University, was
senior health economist with President Reagan’s Council of Economic Advisers. Mr.
Hooper is president of Objective Insights, a firm that consults with pharmaceutical clients.
Appeared in the, print edition

U.S. signs $1.2 bln deal for 1.7 mln courses of Merck's experimental COVID-19 drug

https://www.reuters.com/business/health ... 021-06-09/

but Merck already has an oral anti-viral pill, has had for decades called Ivermectin...why all the add'l spending for such an expensive new drug?

Doesn’t that say OPINION?

Ha ... Mr. "Tried and true" chimes in... Yes, opinions may be correct.

And of course the hit piece, clickbait, misinformation WaPo article was based completely on fact. What a joke...

Once it’s been determined to be effective in treating COVID-19, it will be prescribed…..right now folks in Botswana have nothing to use…..Roots Man swears by root tonics. They also cure COVID-19….try some.

Meaning the belief something can work will juice sales until and/or subsidizing an actual effective drug. Contrary to what some might think would be the case.

[Typical Lax Dad]

https://amp.cnn.com/cnn/2021/08/24/us/c ... index.html

[wgdsr]

recovery has been one of the spots that have been running high powered trials. mostly just hospital stuff and they've had a lot of advantages in the uk system, but at least they're doing work that might do more than raise questions good or bad.

with the number of patients out there i continue to be astounded we haven't prioritized high powered trials.

if i was at the track, monoclonals and maybe interferon would be where i'd place bets at the moment.

[MDlaxfan76]

I think we all know that tech37 is way, way down the rathole of conspiracy nutjobs on these issues.

No one with actual credible expertise is to be trusted, just the whack job snake oil folks...it's "opinions" that go against the consensus of actual experts.... so it must be true!

But hey, he's consistent.

[Typical Lax Dad]

I think we all know that tech37 is way, way down the rathole of conspiracy nutjobs on these issues.

No one with actual credible expertise is to be trusted, just the whack job snake oil folks...it's "opinions" that go against the consensus of actual experts.... so it must be true!

But hey, he's consistent.

“In the first year of the COVID-19 crisis, drug companies have run countless trials to test existing meds against the virus. Drugmakers have also developed novel antibodies to prevent patients’ cases from progressing. On the drug repurposing front, only a handful of medicines—such as Gilead's remdesivir, Eli Lilly’s Olumiant and Roche’s Actemra—have shown promise.”

But Bret Whinestein is all in on Ivermectin….lots of folks trying lots of things.

[MDlaxfan76]

I think we all know that tech37 is way, way down the rathole of conspiracy nutjobs on these issues.

No one with actual credible expertise is to be trusted, just the whack job snake oil folks...it's "opinions" that go against the consensus of actual experts.... so it must be true!

But hey, he's consistent.

“In the first year of the COVID-19 crisis, drug companies have run countless trials to test existing meds against the virus. Drugmakers have also developed novel antibodies to prevent patients’ cases from progressing. On the drug repurposing front, only a handful of medicines—such as Gilead's remdesivir, Eli Lilly’s Olumiant and Roche’s Actemra—have shown promise.”

But Bret Whinestein is all in on Ivermectin….lots of folks trying lots of things.

snake oil promoter

[Typical Lax Dad]

I think we all know that tech37 is way, way down the rathole of conspiracy nutjobs on these issues.

No one with actual credible expertise is to be trusted, just the whack job snake oil folks...it's "opinions" that go against the consensus of actual experts.... so it must be true!

But hey, he's consistent.

“In the first year of the COVID-19 crisis, drug companies have run countless trials to test existing meds against the virus. Drugmakers have also developed novel antibodies to prevent patients’ cases from progressing. On the drug repurposing front, only a handful of medicines—such as Gilead's remdesivir, Eli Lilly’s Olumiant and Roche’s Actemra—have shown promise.”

But Bret Whinestein is all in on Ivermectin….lots of folks trying lots of things.

snake oil promoter

There are people that are convinced root tonic cures Covid. Tech and Bret should promote it.

[Typical Lax Dad]

[Farfromgeneva]

I think we all know that tech37 is way, way down the rathole of conspiracy nutjobs on these issues.

No one with actual credible expertise is to be trusted, just the whack job snake oil folks...it's "opinions" that go against the consensus of actual experts.... so it must be true!

But hey, he's consistent.

I suppose it’s a fine line between empirical skeptic and contrarian/broken dialectic...

[kramerica.inc]

https://www.nbcnews.com/news/us-news/al ... s-n1277316

[jhu72]

As expected, spy agency report is inconclusive.

[tech37]

https://www.nbcnews.com/news/us-news/al ... s-n1277316

So much for the Hippocratic Oath?

This is "Tried And True's" kind of physician