All things CoronaVirus

[PizzaSnake]

Will this catch on in the medical community? Doesn't seem like an unreasonable position.

'In Alabama, where the nation’s lowest vaccination rate has helped push the state closer to a record number of hospitalizations, a physician has sent a clear message to his patients: Don’t come in for medical treatment if you are unvaccinated.

Jason Valentine, a physician at Diagnostic and Medical Clinic Infirmary Health in Mobile, Ala., posted a photo on Facebook this week of him pointing to a sign taped to a door informing patients of his new policy coming Oct. 1.

“Dr. Valentine will no longer see patients that are not vaccinated against covid-19,” the sign reads.

Valentine wrote in the post, which has since been made private but captured in online images, that there were “no conspiracy theories, no excuses” stopping anyone from being vaccinated, AL.com reported. The doctor, who said at least three unvaccinated patients have asked him where they could get a vaccine since he posted the photo, has remained resolute to those who have questioned his decision in recent days.


“If they asked why, I told them covid is a miserable way to die and I can’t watch them die like that,” wrote Valentine, who has specialized in family medicine with Diagnostic and Medical Clinic since 2008.'

https://www.washingtonpost.com/health/2 ... valentine/

Maybe he has a religious edict against consorting with the stupid? "God helps those who help themselves..."

[Typical Lax Dad]

Will this catch on in the medical community? Doesn't seem like an unreasonable position.

'In Alabama, where the nation’s lowest vaccination rate has helped push the state closer to a record number of hospitalizations, a physician has sent a clear message to his patients: Don’t come in for medical treatment if you are unvaccinated.

Jason Valentine, a physician at Diagnostic and Medical Clinic Infirmary Health in Mobile, Ala., posted a photo on Facebook this week of him pointing to a sign taped to a door informing patients of his new policy coming Oct. 1.

“Dr. Valentine will no longer see patients that are not vaccinated against covid-19,” the sign reads.

Valentine wrote in the post, which has since been made private but captured in online images, that there were “no conspiracy theories, no excuses” stopping anyone from being vaccinated, AL.com reported. The doctor, who said at least three unvaccinated patients have asked him where they could get a vaccine since he posted the photo, has remained resolute to those who have questioned his decision in recent days.


“If they asked why, I told them covid is a miserable way to die and I can’t watch them die like that,” wrote Valentine, who has specialized in family medicine with Diagnostic and Medical Clinic since 2008.'

https://www.washingtonpost.com/health/2 ... valentine/

Maybe he has a religious edict against consorting with the stupid? "God helps those who help themselves..."

Don’t want to get vaccinated and you don’t have a valid reason?….go live in a cave with the leprosy folks or get tested daily and pay for your tests.

[youthathletics]

COVID: 90% of patients treated with new Israeli drug discharged in 5 days

https://www.jpost.com/health-science/co ... v0cCcJJ_Oc

[kramerica.inc]

Interestingly, a friend got Covid. Had a myriad of health issues for the past 10 mos. Debilitating and long term for his respiratory, immune system and blood. No cures found, ever shifting symptoms. But he's on his feet. Now his employer is mandating everyone to get a vaccine. Due to his current state and the way the virus messed up his immune system, DRs are advising him any of the vaccines would likely kill him.

What's the solution for the employer?

I haven’t heard or read of a single instance of a mandatory vaccine rule for employment not having exceptions for medical or religious grounds.

I’m guessing a doctor’s note will suffice.

Yup, as long as it's not a quack doc...but sounds like the friend has a legit issue.
So, fall back is regular testing.

It's an odd, unfortunate situation. He's a teacher at a private school, so he could get an exemption, I guess. But transmission/risk for him and others is an issue.

Did his doctor say why he recommends it?

sending you a PM...

[Farfromgeneva]

This is not going to help messaging for booster shots.

People with both COVID-19 shots are fully vaccinated without booster, surgeon general says

https://news.yahoo.com/people-both-covi ... soc_trk=ma

I don’t read that as problematic. He said they are considered fully vaccinated. How many folks who went out by mid summer and got vaccinated are untrusting such that they’d read a problem into what he said. Which included comments on “based on the trajectory we believe a booster will ultimately be needed...”. I read this more as confirmation that the booster isn’t considered officially part of the vaccination. If anything a message to the unvaccinated community that “were not going to string you along forever with boosters and we still think the primary shots are sufficient in our official govt view”. He also specifically references Moderna I believe but not J&J or Pfizer (I have Pfizer)

I’ve read and heard this could be a yearly booster. First time I’ve read no need for a booster for those fully vaccinated.

Well it was stated “as of now” and the official position-just talking for now.

[kramerica.inc]

Even Garth is doing the responsible thing....

Garth Brooks cancels 5 NFL stadium shows triggering 350,000 ticket refunds:

https://profootballtalk.nbcsports.com/2 ... a-variant/

[ggait]

COVID: 90% of patients treated with new Israeli drug discharged in 5 days

https://www.jpost.com/health-science/co ... v0cCcJJ_Oc

Did you bother to read this article YA?

1. This is a phase II study. As the article says, the purpose of that study is to determine safety, not efficacy.

2. The article says 95% of Covid patients do not need any therapy at all. So a 90% success rate for moderate/severe may not be particularly impressive.

Check back at year end. Which is when they will have first data of treated vs. placebo.

Seems like this drug is mostly being touted as safer, not more effective, than existing treatments (like steroids).

[Typical Lax Dad]

COVID: 90% of patients treated with new Israeli drug discharged in 5 days

https://www.jpost.com/health-science/co ... v0cCcJJ_Oc

Did you bother to read this article YA?

1. This is a phase II study. As the article says, the purpose of that study is to determine safety, not efficacy.

2. The article says 95% of Covid patients do not need any therapy at all. So a 90% success rate for moderate/severe may not be particularly impressive.

Check back at year end. Which is when they will have first data of treated vs. placebo.

Seems like this drug is mostly being touted as safer, not more effective, than existing treatments (like steroids).

Pharmaceutical executive told me last year that treatments have improved considerably in hospitals. Steroids were a big help.

[Carroll81]

COVID: 90% of patients treated with new Israeli drug discharged in 5 days

https://www.jpost.com/health-science/co ... v0cCcJJ_Oc

Did you bother to read this article YA?

1. This is a phase II study. As the article says, the purpose of that study is to determine safety, not efficacy.

2. The article says 95% of Covid patients do not need any therapy at all. So a 90% success rate for moderate/severe may not be particularly impressive.

Check back at year end. Which is when they will have first data of treated vs. placebo.

Seems like this drug is mostly being touted as safer, not more effective, than existing treatments (like steroids).

ggait, you beat me to the punch. My first question when I read the lead was, "How many would have walked out anyways?". I went back and referenced the gene they talk about in the article. If you want a good read about controlling the cytokine storm and the immune system in general, I highly recommend:

An elegant defense : the extraordinary new science of the immune system : a tale in four lives / Matt Richtel.

[wgdsr]

An interesting take on the data for waning efficacy in Israel.

https://www.covid-datascience.com/post/ ... vaccinated

thanks, bart. excellent article for the amateurs out here like me. had been searching out israel results and takes more than others as they were 1st to bat (although some confounding on past disease, one shotters and boosters as he mentions). but as they're in a surge, we're fortunate to have their info. small country so death data maybe won't be as good (but good for them). hopefully any waning is muted, and numbers like 80s and 90s % can stick.

Yes, thanks Bart. It is a good analysis, unfortunately there are some typos and the way he presents his tables sucks. Takes a bit to read it, review the tables and then go back and check the math. Reading the crazy comments helped me figure out his tables. It also shows how easy it is to mess up the math and how many confounding factors there are.

wgsdr, do you agree with his conclusions? Trying to look at the raw data myself, but Google Translate is struggling with ti.

i mean, i'm a novice. i think he just put this together to give some covid for dummies analysis together and it's helpful. i was familiar with the basics on it and tried to post on it this weekend some (not nearly as well or detailed) from the standpoint of messaging, essentially. he's doing it, too, and rightfully taking the "don't freak out" view.
he's using one data point essentially (515 in israeli hospitals), and there's confounding. not much from him on waning because of that, and the picture is small sample, especially when you break it up. but that isn't his priority.

just tutorial.

i ran across this mit gig over the weekend, has a lot of useful links. and the cdc leaked doc to the post has them doing similar with even a a smaller stowe, et al study from june:
https://medical.mit.edu/covid-19-update ... infections
they're probably getting loads more info by the day. i still haven't looked up yesterday's? israel waning info that prompted:
https://www.cnbc.com/2021/08/18/covid-b ... idappshare

we'll have more data. i'm not sure whether it matters if it's 75%, 85%, 92% as long as we're tracking to make best policy. to that end, i think we have so far.

messaging maybe not as great, but honestly there are folks that are in the "messaging doesn't matter as much as carrots/sticks camp" and i really couldn't handicap either. can't say they're wrong.

[Typical Lax Dad]

COVID: 90% of patients treated with new Israeli drug discharged in 5 days

https://www.jpost.com/health-science/co ... v0cCcJJ_Oc

Is Ivermectin off the table now?

[youthathletics]

COVID: 90% of patients treated with new Israeli drug discharged in 5 days

https://www.jpost.com/health-science/co ... v0cCcJJ_Oc

Is Ivermectin off the table now?

ask ggait...he has all the answers.

[PizzaSnake]

COVID: 90% of patients treated with new Israeli drug discharged in 5 days

https://www.jpost.com/health-science/co ... v0cCcJJ_Oc

Is Ivermectin off the table now?

"“Through the Spring we got better data. That says it doesn’t. So, now we have to let it go. We’ve tried lots of things during this pandemic, some have worked, some have not. Ivermectin doesn’t work,” said Dr. O’Neal.

Dr. Aldo Russo over at Ochsner Baton Rouge agrees.

“It appeared to have some sort of effect on the virus in-vitro, meaning in the lab. Now when the research continued in humans with COVID-19, the medication was not beneficial at all,” said Dr. Aldo Russo, Regional Medical Director for Ochsner Baton Rouge."

https://www.wafb.com/2021/08/17/we-have ... -covid-19/

[PizzaSnake]

Regarding ivermectin efficacy, see the following article in Nature:

https://www.nature.com/articles/d41586-021-02081-w

"Throughout the pandemic, the anti-parasite drug ivermectin has attracted much attention, particularly in Latin America, as a potential way to treat COVID-19. But scientists say that recent, shocking revelations of widespread flaws in the data of a preprint study reporting that the medication greatly reduces COVID-19 deaths dampens ivermectin’s promise — and highlights the challenges of investigating drug efficacy during a pandemic.

“I was shocked, as everyone in the scientific community probably were,” says Eduardo López-Medina, a paediatrician at the Centre for the Study of Paediatric Infections in Cali, Colombia, who was not involved with the study and who has investigated whether ivermectin can improve COVID-19 symptoms. “It was one of the first papers that led everyone to get into the idea ivermectin worked” in a clinical-trial setting, he adds."

"The paper’s irregularities came to light when Jack Lawrence, a master’s student at the University of London, was reading it for a class assignment and noticed that some phrases were identical to those in other published work. When he contacted researchers who specialize in detecting fraud in scientific publications, the group found other causes for concern, including dozens of patient records that seemed to be duplicates, inconsistencies between the raw data and the information in the paper, patients whose records indicate they died before the study’s start date, and numbers that seemed to be too consistent to have occurred by chance."

"patients whose records indicate they died" -- like Republican voters who vote when they are dead?

[Typical Lax Dad]

COVID: 90% of patients treated with new Israeli drug discharged in 5 days

https://www.jpost.com/health-science/co ... v0cCcJJ_Oc

Is Ivermectin off the table now?

"“Through the Spring we got better data. That says it doesn’t. So, now we have to let it go. We’ve tried lots of things during this pandemic, some have worked, some have not. Ivermectin doesn’t work,” said Dr. O’Neal.

Dr. Aldo Russo over at Ochsner Baton Rouge agrees.

“It appeared to have some sort of effect on the virus in-vitro, meaning in the lab. Now when the research continued in humans with COVID-19, the medication was not beneficial at all,” said Dr. Aldo Russo, Regional Medical Director for Ochsner Baton Rouge."

https://www.wafb.com/2021/08/17/we-have ... -covid-19/

Will a positive attitude make it work better?

[PizzaSnake]

COVID: 90% of patients treated with new Israeli drug discharged in 5 days

https://www.jpost.com/health-science/co ... v0cCcJJ_Oc

Is Ivermectin off the table now?

"“Through the Spring we got better data. That says it doesn’t. So, now we have to let it go. We’ve tried lots of things during this pandemic, some have worked, some have not. Ivermectin doesn’t work,” said Dr. O’Neal.

Dr. Aldo Russo over at Ochsner Baton Rouge agrees.

“It appeared to have some sort of effect on the virus in-vitro, meaning in the lab. Now when the research continued in humans with COVID-19, the medication was not beneficial at all,” said Dr. Aldo Russo, Regional Medical Director for Ochsner Baton Rouge."

https://www.wafb.com/2021/08/17/we-have ... -covid-19/

Will a positive attitude make it work better?

Who know? Placebo effect is real.

However, I'm going to go with, "wish in one hand..."

[wgdsr]

COVID: 90% of patients treated with new Israeli drug discharged in 5 days

https://www.jpost.com/health-science/co ... v0cCcJJ_Oc

Is Ivermectin off the table now?

"“Through the Spring we got better data. That says it doesn’t. So, now we have to let it go. We’ve tried lots of things during this pandemic, some have worked, some have not. Ivermectin doesn’t work,” said Dr. O’Neal.

Dr. Aldo Russo over at Ochsner Baton Rouge agrees.

“It appeared to have some sort of effect on the virus in-vitro, meaning in the lab. Now when the research continued in humans with COVID-19, the medication was not beneficial at all,” said Dr. Aldo Russo, Regional Medical Director for Ochsner Baton Rouge."

https://www.wafb.com/2021/08/17/we-have ... -covid-19/

Will a positive attitude make it work better?

Who know? Placebo effect is real.

However, I'm going to go with, "wish in one hand..."

stick with monoclonals for now if you qualify? it's on the
house.

[Bart]

COVID: 90% of patients treated with new Israeli drug discharged in 5 days

https://www.jpost.com/health-science/co ... v0cCcJJ_Oc

Did you bother to read this article YA?

1. This is a phase II study. As the article says, the purpose of that study is to determine safety, not efficacy.

2. The article says 95% of Covid patients do not need any therapy at all. So a 90% success rate for moderate/severe may not be particularly impressive.

Check back at year end. Which is when they will have first data of treated vs. placebo.

Seems like this drug is mostly being touted as safer, not more effective, than existing treatments (like steroids).

You are right. Article says 95% of the patients do not need treatment. The remaining 5% deteriorate after 5-12 days due in part to the immune systems incorrect cytokine storm. This CD24 blocker appears to help the remaining 5%. If you can help 90% of that 5% that would be fantastic. At least that is how I interpreted it....

Now this particular molecule seems to have been touted previously for other things like cancer treatment. So while I hope it works out you are 100% correct the proof will come in the larger 155 patient RCT. I hope it does but like most things phase I and II mean little if phase III falls flat on its face.

This site is real interesting. I has a bunch of treatments and vaccines they rank from front runner to...errrrr mabee? There are some interesting things on it but you will notice that the treatment discussed above is not. That does not mean it will not pan out but not on the front runner list for this site. It is an interesting place if you want to rummage around for a while to see what is out there.

https://www.genengnews.com/category/cov ... nt-runner/

[Farfromgeneva]

Even Garth is doing the responsible thing....

Garth Brooks cancels 5 NFL stadium shows triggering 350,000 ticket refunds:

https://profootballtalk.nbcsports.com/2 ... a-variant/

I can’t believe 350,000 folks care more about A Garth Brooks show at this point than a football game.

[ggait]

Article says 95% of the patients do not need treatment. The remaining 5% deteriorate after 5-12 days due in part to the immune systems incorrect cytokine storm. This CD24 blocker appears to help the remaining 5%. If you can help 90% of that 5% that would be fantastic. At least that is how I interpreted it....

That's a good reading. Thanks.

However, the underlying reality is that close to all of the 5% are in the 5% for one reason. They failed to get vaxed.

Take the shot, and you'll have close to zero need for a Covid therapeutic.