… its not the steroids that make it a bad study - it is the methodology. Substitute aspirin for the steroids in as uncontrolled fashion as these guys did - its a bad study. Maybe there is some insight someone can glean from this "survey". What cannot be said is HCQ is either safe or effective.wgdsr wrote: ↑Sun Jul 05, 2020 12:58 pmyeah, mSOFAs, cox regressions, was there only 1 O2 divider? can't take any study seriously that's trying to match propensity scores with significantly diff groups. the non-treatment group is on ave 5 years older and we've got a hyperbolic mortality curve. doesn't work. glad the largest cohort had a good survival rate, but meh.jhu72 wrote: ↑Sun Jul 05, 2020 12:03 pm-- nope. The study actually indicated that HCQ alone was the solution. Every other combination of drugs they tested, their data showed as less effective than HCQ alone. Well, except for the fact that they were giving steroids to some patients, mostly the ones on "HCQ alone", but they were not counted in the mix. Its a bad study.MDlaxfan76 wrote: ↑Sun Jul 05, 2020 11:01 amnope, I didn't call it a joke, that was another poster.Peter Brown wrote: ↑Sun Jul 05, 2020 8:14 am Hey just last week MD was on here calling the Henry Ford Hospital study a joke. Weird I keep reading articles like this then:
https://www.sentinel-standard.com/news/ ... ents-lives
I actually said it was interesting, and potentially a positive roadmap, but not a double-blind controlled study.
I did say that anyone thinking this study had proven that HCQ actually works as a prophylactic measure, or was a 'cure', would be wrong.
Maybe, just maybe, it is helpful in combination with other drugs, at a specific time in the disease's progress and for some patients, though perhaps not others. And maybe that help is better than the help from alternative therapies.
Maybe. Deserves study? Sure.
outside of a study showing a drug is hitting it out of the park, and have similar cohorts, they're not tremendously useful the way they're constructed. unfortunately, similar poor trials have been pushed as some grave danger re: hcq, when that simply does not seem to be the case. and that's impacted the work.
disappointing we haven't been producing real clinical trial work for this and other drugs by now with all the cases and tech at our disposal, but maybe we're on the verge? we'll see.
That largest cohort was also the least ill to begin with. What was not done was an identical cohort with no medication. The medical community will not change their minds about HCQ based on this "survey".