well, thanks tech, though i'm not so sure that's such a high bar!tech37 wrote: ↑Thu Jun 11, 2020 2:58 pmThanks for posting this wgdsr, even for an "amateur"wgdsr wrote: ↑Thu Jun 11, 2020 2:41 pm https://www.hospimedica.com/covid-19/ar ... cells.html
https://www.nature.com/articles/s41586-020-2349-y
didn't see this when study came out in may. not sure if someone posted or commented on it.
sounds promising. sars patient from 2003 has antibodies, particularly one of them that may/may not be better in combination with other mAbs from sars, that neutralize the covid 2 virus in vitro and might kick up the immune system as well.
some possible other benefits if true in real life?
- immunity-ish for people who contract covid 2. maybe even long term. this is a stab from an amateur, but at least it sounds reasonable. is S309 or something similar acting in the covid 2 antibody mix?
- vir biotechnology (along with gsk) can evidently turn it around into a therapeutic and maybe vaccine.
- mechanism/timing/target? to neutralize in the disease process also makes it difficult for virus to mutate on it to render the antibody ineffective.
- we have been warned more coronaviruses are coming in the future.
CSO Herbert "Skip" Virgin, M.D., Ph.D., says, “Remarkably, we believe S309 likely covers the entire family of related coronaviruses, which suggests that, even as SARS-CoV-2 continues to evolve, it may be quite challenging for it to become resistant to the neutralizing activity of S309. In addition, S309 exhibits potent effector function in vitro, potentially allowing the antibody to engage and recruit the rest of the immune system to kill off already infected cells. We have seen in animal models of other respiratory infections, such as influenza, that effector function significantly enhances the activity of antibodies that are already potently neutralizing.”
vir also has a recent post up about all that's necessary to get things going on a faster path in a pandemic, posted about this very route in april in nature as well by dr. brian kelley, sr vp of process development and manuf:
https://www.nature.com/articles/s41587-020-0512-5
before i get ahead of myself, yes, it was in the lab. hcq was effective in vitro and of course lots of people have said that doesn't work. however, mAbs- monoclonal antibodies have had the most success vs the very deadly ebola virus, and without trials really being an option. and vir has a big time partner here in gsk. they also work with bill and melinda on something.
Let's hope we see a sequel to this in the Good News thread in the not too distant future.
BTW, you probably know more than 90% of CDC and WHO combined...
Now where is Bart, another favorite amateur microbiologist on here, to concur?
wear a mask, don't wear a mask, this study looks troubling over coffee, cancel everything.
wait... (perusing random dark web email thread).... there's asymptomatic transmission?!?!? are you sure? we're screwed! we've been contaminating our own tests for a month and change with no rush bc this was gonna be easy! - cdc
intl travel from wuhan should be fine, don't worry about those crematoriums.
so months later we now think asymptomatic transmission is very rare... next day -- wait, we misspoke!
we're in great hands.